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SARM1 产品

(Sterile alpha and TIR Motif Containing 1 (SARM1))

Categories

Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation (By similarity).

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Featured SARM1 Categories

SARM1 抗体

High quality antibodies with extensive validation data.

SARM1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SARM1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF (p), IHC (p)
Validations
  • (2)
Cat. No. ABIN1387556
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p), IF, ICC, IHC
Validations
  • (2)
Cat. No. ABIN213875
Quantity 0.05 mg
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (2)
Cat. No. ABIN7270591
Quantity 100 μL
Datasheet Datasheet

Recommended SARM1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6207518
Quantity 96 tests
Datasheet Datasheet

Recommended SARM1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN3135795
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN3095302
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2731405
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our SARM1 Products

Rodet, Tasiemski, Boidin-Wichlacz, Van Camp, Vuillaume, Slomianny, Salzet: "Hm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leech." in: Scientific reports, Vol. 5, pp. 9624, (2015) (PubMed).

Chintala, Putris, Geno: "Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3." in: Investigative ophthalmology & visual science, Vol. 56, Issue 1, pp. 505-14, (2015) (PubMed).

Murata, Sakaguchi, Kataoka, Huh: "SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria." in: Molecular biology of the cell, Vol. 24, Issue 18, pp. 2772-84, (2013) (PubMed).

Massoll, Mando, Chintala: "Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons." in: Investigative ophthalmology & visual science, Vol. 54, Issue 4, pp. 2771-80, (2013) (PubMed).

Li, Moore, Vasilieva, Sui, Wong, Berne, Somasundaran, Sullivan, Luzuriaga, Greenough, Choe, Farzan: "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus." in: Nature, Vol. 426, Issue 6965, pp. 450-4, (2003) (PubMed).

ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, (2003) (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, (2003) (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, (2002) (PubMed).

Synonyms and alternative names related to SARM1

sterile alpha and TIR motif containing 1 (SARM1), sterile alpha and HEAT/Armadillo motif containing 1 (Sarm1), sterile alpha and TIR motif containing 1 (Sarm1), sterile alpha and TIR motif containing 1 (sarm1), A830091I15Rik, C78606, MyD88-5, MyD885, SAMD2, Sarm, SARM

Protein level used designations for SARM1

  • sterile alpha and TIR motif-containing protein 1
  • sterile alpha and TIR motif containing 1
  • Tir-1 homolog
  • SAM domain-containing protein 2
  • sterile alpha and Armadillo repeat protein
  • sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
  • sterile alpha motif domain-containing protein 2
  • tir-1 homolog
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