Use your antibodies-online credentials, if available.
Select your species
NFAT2 is an important regulator for the anergic phenotype of chronic lymphocytic leukaemia.
NFATc1 controls the cytotoxicity and metabolic switching of activated CD8 (显示 CD8A ELISA试剂盒)(+) T cells required for optimal response to bacteria and tumor cells.
ATF3 (显示 ATF3 ELISA试剂盒) is a new co-factor of c-Fos and NFATc1 to activate osteoclast differentiation and activity.
NFAT is activated through calcineurin and interacts with NFsmall ka, CyrillicB after P. aeruginosa lung infection, and contributes to the host inflammatory response.
IKKepsilon (显示 IKBKE ELISA试剂盒) promotes NFATc1 phosphorylation and inhibits T cell responses, identifying IKKepsilon (显示 IKBKE ELISA试剂盒) as a crucial negative regulator of T cell activation and a potential target for immunotherapy.
Transplantation from GRIM19 (显示 NDUFA13 ELISA试剂盒)-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1) but promoted the expression of regulator of calcineurin (RCAN)3 (显示 RCAN3 ELISA试剂盒) while downregulating NFAT-dependent cytokine gene expression.
These results suggest that the Keap1 (显示 KEAP1 ELISA试剂盒)/Nrf2 (显示 NFE2L2 ELISA试剂盒) axis plays a critical role in NFATc1 expression and osteoclastogenic progression.
Inhibition of calcineurin activity with FK506 or blockage of L-type calcium channels with nifedipine significantly suppressed NFATc1 mRNA expression and CTSK (显示 CTSK ELISA试剂盒) protein expression.
astrocytes were strongly associated with proteolysis of the protein phosphatase calcineurin (CN) and the elevated expression of the CN-dependent transcription factor nuclear factor of activated T cells 4 (NFAT4 (显示 NFATC3 ELISA试剂盒)
In studies of human and mouse pancreatic cells and tissue, we identified context-specific epigenetic regulation of NFATc1 activity as an important mechanism of pancreatic cell plasticity.
Exposure to UVB radiation induces nuclear translocation and stimulates binding between NFAT5 (显示 NFAT5 ELISA试剂盒) and NF-kappaB (显示 NFKB1 ELISA试剂盒) proteins in HLE (显示 ELANE ELISA试剂盒)-B3 cells. These interactions may form part of the biochemical mechanism of cataractogenesis in UVB-irradiated HLECs.
data identified a novel role of SFKs in preventing aberrant NFAT1 (显示 NFAT1 ELISA试剂盒) activation in resting T cells, and suggest that maintaining this pool of active SFKs in therapeutic T cells may increase the efficacy of T cell therapies
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (显示 LYST ELISA试剂盒) (cg16962115, FDR = 1.24E-04), CADM1 (显示 CADM1 ELISA试剂盒) (cg21933078, FDR = 1.22E-02) and NFATC1 (cg06784563, FDR = 1.46E-02)
there is an NFATc1/ABCA1 (显示 ABCA1 ELISA试剂盒)-dependent mechanism in which local TNF (显示 TNF ELISA试剂盒) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (显示 TNF ELISA试剂盒), TNFR1 (显示 TNFRSF1A ELISA试剂盒), or TNFR2 (显示 TNFRSF1B ELISA试剂盒) serum levels
NFATC1 transcription factor (NFATc1) expression is detected in prostate cancer (PCa (显示 FLVCR1 ELISA试剂盒)) specimens and PCa (显示 FLVCR1 ELISA试剂盒) cells but is absent in non-neoplastic human prostates and non-tumorigenic prostatic cells
DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.
NFATC1 rs3894049 GC was a risk factor for acute rejection in renal transplant recipients compared with CC carriers.
revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 (显示 NFAT1 ELISA试剂盒) in T cells, such as Raptor (显示 RPTOR ELISA试剂盒), CHEK1 (显示 CHEK1 ELISA试剂盒), CREB1 (显示 CREB1 ELISA试剂盒), RUNX1 (显示 RUNX1 ELISA试剂盒), SATB1 (显示 SATB1 ELISA试剂盒), Ikaros (显示 IKZF1 ELISA试剂盒), and Helios (显示 ZNFN1A2 ELISA试剂盒).
In calf pulmonary artery endothelial cells, extracellular application of vasoactive agonist ATP or calcium ionophore ionomycin generates a rise in intracellular calcium that induces nuclear localization of NFATc1.
regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
, nuclear factor of activated T-cells, cytosolic component 1
, nuclear factor of activated T-cells calcineurin-dependent 1
, nuclear factor of activated T-cells, cytoplasmic 1
, nuclear factor of activated T-cells, cytoplasmic 1-like
, NFAT transcription complex cytosolic component
, transcription factor NF-ATc
, transcription factor NFATmac