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抗Human IGF1 抗体:
抗Mouse (Murine) IGF1 抗体:
抗Rat (Rattus) IGF1 抗体:
Human Polyclonal IGF1 Primary Antibody for IF (p), IHC (p) - ABIN723605
Baykara, Aksu, Buyuk, Kiray, Sisman, Baykara, Dayi, Tas, Ozdemir, Arda, Uysal et al.: Progesterone treatment decreases traumatic brain injury induced anxiety and is correlated with increased serum IGF-1 levels; prefrontal cortex, amygdala, hippocampus neuron density; and reduced serum ... in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2013
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Human Polyclonal IGF1 Primary Antibody for IHC (p), WB - ABIN3044390
Li, Zhang, Li, Zhao, Zhai, Yang, Kong, Wu, Chen, Teng: miR-18a counteracts AKT and ERK activation to inhibit the proliferation of pancreatic progenitor cells. in Scientific reports 2017
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Mouse (Murine) Polyclonal IGF1 Primary Antibody for WB - ABIN4321494
Go, Srivastava, Hernandez-Ono, Gang, Smith, Booth, Ginsberg, Mani: The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. in Cell metabolism 2014
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Human Polyclonal IGF1 Primary Antibody for IHC (p), WB - ABIN966342
Jansen, van Schaik, Ricker, Bullock, Woods, Gabbay, Nussbaum, Sussenbach, Van den Brande: Sequence of cDNA encoding human insulin-like growth factor I precursor. in Nature 1984
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Human Polyclonal IGF1 Primary Antibody for ELISA, IHC - ABIN1586056
Malempati, Weigel, Ingle, Ahern, Carroll, Roberts, Reid, Schmechel, Voss, Cho, Chen, Krailo, Adamson, Blaney: Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012
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Human Polyclonal IGF1 Primary Antibody for ICC, IF - ABIN4321496
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. in Molecular pharmaceutics 2015
Human Polyclonal IGF1 Primary Antibody for ELISA, WB - ABIN4321495
Furundzija, Fritzsche, Kaufmann, Meyborg, Fleck, Kappert, Stawowy: IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling. in Biochemical and biophysical research communications 2010
Human Polyclonal IGF1 Primary Antibody for ELISA, WB - ABIN2474319
Singer, Mogg, Koestler, Pacher, Marton, Kubista, Schreiber: Insulin-like growth factor (IGF)-I and IGF-II serum concentrations in patients with benign and malignant breast lesions: free IGF-II is correlated with breast cancer size. in Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Human Polyclonal IGF1 Primary Antibody for ELISA, WB - ABIN561442
Herrero-Martín, Osuna, Ordóñez, Sevillano, Martins, Mackintosh, Campos, Madoz-Gúrpide, Otero-Motta, Caballero, Amaral, Wai, Braun, Eisenacher, Schaefer, Poremba, de Alava: Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target. in British journal of cancer 2009
Human Polyclonal IGF1 Primary Antibody for Neut, ELISA - ABIN223533
Lewy, Ryan, Read, Fong, Poole, Seed, Sharma, Smith, Kwan, Stewart, Bacon, Warfield, Franklyn, McCabe, Boelaert: Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells. in Endocrinology 2013
A large sequence divergence of the C-terminal domain (C-Ala) reshaped C-Ala in a way that changed the global architecture of alanyl-tRNA synthetase (AlaRS). This reshaping removed the role of C-Ala in prokaryotes for docking tRNA and instead repurposed it to form a dimer interface presenting a DNA-binding groove.
the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer (Review)
Circulating Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 (显示 IGFBP3 抗体) predict Three-months Outcome after Ischemic Stroke.
These findings reveal that IGFBP3 (显示 IGFBP3 抗体) is effective in lung cancer cells with high IGF1 signaling activity and imply that relevant biomarkers are essential in selecting lung cancer patients for IGF1-targeted therapy
These data support the hypothesis that down regulation of the insulin (显示 INS 抗体)-like growth factor (IGF-I) signaling links decidual phosphorylated insulin (显示 INS 抗体)-like growth factor-binding protein (IGFBP-1 (显示 IGFBPI 抗体)) hyperphosphorylation to restricted fetal growth in placental insufficiency.
These data implicate insulin (显示 INS 抗体) resistance as a potential suppressor of IGF-I-dependent cortical bone development.
Study found that exercise increased hippocampal IGF-I levels only in cycling females through estrogen stimulation. These results suggest that sex-specific brain IGF-I responses to physiological stimuli such as exercise contribute to dimorphic mood homeostasis that may explain sex differences in affective disorders.
The results show that IGF1 levels were lower in NAFLD (显示 TSC2 抗体) patients and suggest that the growth hormone (显示 GH1 抗体)-IFG1 system may be involved in the pathogenesis of NAFLD (显示 TSC2 抗体).
In type 2 diabetic patients insulin (显示 INS 抗体) glargine depressed the serum IGF1 levels much more when compared to insulin (显示 INS 抗体) detemir.
High IGF-1 serum levels are associated with breast cancer.
RIP3 (显示 MPRIP 抗体) and phosphorylated MLKL expressions were relatively decreased in the IGF-1 receptor monoclonal antibody group compared to the non-treated group. IGF-1 may be associated with RIP3 (显示 MPRIP 抗体)-mediated necroptosis in vitro, while blocking of the IGF-1 pathway may reduce LPS (显示 TLR4 抗体)-induced lung injuries in vivo.
The down-regulation of IGF-I signaling, as observed in old mice, leads to increasing the activity of FoxO (显示 FOXO3 抗体) factors that may be important for the neuroprotective effects seen with dietary restriction.
Data suggest that gut (显示 GUSB 抗体) resident bacteria-derived short-chain fatty acids mediate microbiota induced changes in host IGF-1 levels and contribute to the effects of colonization on bone turnover.
High IGF1 expression is sensitive to initial injury intensity induced by freeze damage.
study revealed that only BMP-6 (显示 BMP6 抗体) was able to induce bone formation at the used dose and that the addition of IGF-1 contributed to an increase of the mineralization in the implants. Hence, the combination of BMP-6 (显示 BMP6 抗体) with IGF-1 might be a better alternative than BMP-2 (显示 BMP2 抗体) for orthopedic surgery or bone tissue engineering approaches.
IGF-1 signaling in involved in the epithelial-mesenchymal transformation of B16-F10 (显示 F10 抗体) cells and in the control of the stem cell phenotype.
Findings provided morphological evidence that T-type Cav3.2 (显示 CACNA1H 抗体) channel, at least partially, mediates the pain facilitation of insulin-like growth factor-1/insulin-like growth factor-1 receptor (显示 IGF1R 抗体) signaling in chronic inflammatory pain condition.
Conditional deletion of IGF-1 in osteocytes enhanced bony union of the fracture gap in a tibial fracture model.
IGF-I stimulated IRS-1 (显示 IRS1 抗体) phosphorylation and recruitment of PKCzeta (显示 PRKCZ 抗体) and vimentin (显示 VIM 抗体) to phospho-IRS-1 (显示 IRS1 抗体).
local IGF-I plays critical roles during postnatal/adult hippocampal neurogenesis.
the dipeptide Pro-Asp (显示 ASIP 抗体) promoted IGF-1 secretion and expression in hepatocytes.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (显示 FRAP1 抗体) and PPARg (显示 PPARG 抗体). In summary, PPARg (显示 PPARG 抗体) plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (显示 HGF 抗体) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
Results show that expression changes of IGF1 genes were associated with C/EBP (显示 CEBPA 抗体) b expression during embryonic and postnatal development in porcine liver.
genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.
IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.
IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.
alpha-linolenic acid increased IGF-I secretion from hepatocytes.
Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin (显示 LEP 抗体) on cell proliferation/apoptosis, MAP kinase (显示 MAPK1 抗体) signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin (显示 LEP 抗体). (IGF1 = insulin-like growth factor I)
Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.
Our studies demonstrate that the active SVCT2 (显示 SLC23A2 抗体) is expressed in IVD (显示 IVD 抗体) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (显示 INS 抗体) and IGF.
IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors
Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.
Findings show similar regulatory growth hormone (GH (显示 GH1 抗体)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (显示 INS 抗体)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (显示 TNF 抗体).
Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.
Study demonstrated that IGF-I can stimulate egfr (显示 EGFR 抗体) expression in both follicles cell culture and intact follicles promoting oocyte maturation.
IGF-I-induced kitlga expression is inhibited by epidermal growth factor (显示 EGF 抗体), an oocyte-derived paracrine factor in the zebrafish follicle.
hypoxia causes PGC (显示 PGC 抗体) migration defect by inhibiting IGF signaling through the induction of IGFBP-1 (显示 IGFBPI 抗体)
Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt (显示 AKT1 抗体) signaling activities, re-oxygenation restored their activities
IGF signalling influences expression of BMP2b (显示 BMP4 抗体), a gene that plays an important role in zebrafish pattern formation
The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts
zebrafish XBP-1 (显示 XBP1 抗体) spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt (显示 AKT1 抗体) pathway in unfolded protein
IGF1/RsaI was associated with average daily weight gain in cattle.
Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 (显示 STAT5A 抗体) ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.
The association of IGF1, GH, and PIT1 (显示 POU1F1 抗体) markers with growth and reproductive traits were assessed.
These findings strongly support the concept that IGF-1 upregulates LHR (显示 LHCGR 抗体) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
Insulin (显示 INS 抗体)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (显示 MAPK1 抗体)-mediated signaling pathways.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (显示 IGFBP3 抗体)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
The laminar cell types expressing insulin receptor (显示 INSR 抗体) and/or insulin-like growth factor-1 receptor (显示 IGF1R 抗体) and the effect of dietary carbohydrates on their expression are reported.
Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.
Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (显示 IGF1R 抗体) is present in spermatogonia, spermatocytes and Leydig cells.
Hsp90 (显示 HSP90AB1 抗体) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.
Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.
Relative expression of IGF1 was highest in uterus and liver (P < 0.05), followed by oviduct and muscle. This work provided an important experimental basis for further research on the functions of IGF1 in goats.
These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.
Relative levels of IGF-I and MSTN (显示 MSTN 抗体) mRNA may participate in ordering duck muscle growth rates with selected development.
Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
, alanine tRNA ligase 1, cytoplasmic
, alanine--tRNA ligase, cytoplasmic
, alanyl-tRNA synthetase, cytoplasmic
, renal carcinoma antigen NY-REN-42
, insulin-like growth factor 1
, insulin-like growth factor I
, insulin-like growth factor IA
, insulin-like growth factor IB
, mechano growth factor
, somatomedin C
, insulin-like growth factor-1
, Insulin-like growth factor I
, class 1 insulin-like growth factor I preproprotein
, insulin growth factor-1
, insulin like growth factor 1
, insulin-like growth factor I (somatomedin C)
, insulin-like growth factor I variant 1
, insulin like growth factor-1
, insulin-like growth factor-I
, insulin-like growth factor 1 (somatomedin C)
, insulin like growth factor 1 S homeolog
, insulin-like growth factor I-A