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抗Human BDNF 抗体:
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抗Mouse (Murine) BDNF 抗体:
Human Polyclonal BDNF Primary Antibody for WB - ABIN3043096
Shi, Shao, Yuan, Pan, Li: Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. in Yonsei medical journal 2010
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Mouse (Murine) Polyclonal BDNF Primary Antibody for IHC (p), WB - ABIN3043798
Li, Xia, Zhang, Wu: S100B protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk. in PLoS ONE 2011
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Dog (Canine) Polyclonal BDNF Primary Antibody for IHC, WB - ABIN2777093
Hashimoto, Moriguchi, Yamashita, Mori, Nemoto, Okada, Hori, Noguchi, Kunugi, Ohnishi: Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity. in Neuroscience research 2008
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Human Polyclonal BDNF Primary Antibody for CyTOF, FACS - ABIN4899237
Xapelli, Bernardino, Ferreira, Grade, Silva, Salgado, Cavadas, Grouzmann, Poulsen, Jakobsen, Oliveira, Zimmer, Malva: Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia. in The European journal of neuroscience 2008
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Human Polyclonal BDNF Primary Antibody for DB, IHC (fro) - ABIN542616
Pezet, Malcangio, McMahon: BDNF: a neuromodulator in nociceptive pathways? in Brain research. Brain research reviews 2003
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Human Polyclonal BDNF Primary Antibody for IHC, WB - ABIN6672757
Hang, Zhao, Sun, Li, Han, Du, Li: Brain-derived neurotrophic factor attenuates doxorubicin-induced cardiac dysfunction through activating Akt signalling in rats. in Journal of cellular and molecular medicine 2017
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Mouse (Murine) Polyclonal BDNF Primary Antibody for IHC, WB - ABIN3021893
Sidler, Aitken, Jiang, Sotiropoulos, Aggarwal, Anees, Chong, Siebenaller, Thanabalasingam, White, Choufani, Weksberg, Sangiorgi, Wrana, Delgado-Olguin, Bägli et al.: DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of ... in The American journal of pathology 2018
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Human Polyclonal BDNF Primary Antibody for IF (p), IHC (p) - ABIN1387788
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. in Neurobiology of disease 2014
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Human Polyclonal BDNF Primary Antibody for WB - ABIN548503
Jones, Reichardt: Molecular cloning of a human gene that is a member of the nerve growth factor family. in Proceedings of the National Academy of Sciences of the United States of America 1990
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Human Polyclonal BDNF Primary Antibody for IHC, IHC (p) - ABIN4283816
Hasan Mahmood, Uddin, Ibrahim, Mandal, Alhamami, Briski et al.: Sex differences in forebrain estrogen receptor regulation of hypoglycemic patterns of counter-regulatory hormone secretion and ventromedial hypothalamic nucleus glucoregulatory neurotransmitter and ... in Neuropeptides 2018
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A significant inverse correlation between body mass index and BDNF levels was found only in female schizophrenic patients.
BDNF appears to be a new interesting biomarker for MPM and could also be a new therapeutic target regarding its implication in angiogenesis.
There was a strong negative correlation between Full Scale IQ scores and the Early Trauma Inventory General Events scores after age 18 years in the Met allele carriers only. Likewise, the Perceptual Organization Index was negatively correlated with general trauma after age 18 years (r=-0.682 p=0.007) in the Met allele carriers only.
PTSD was associated with decreased methylation at three BDNF CpG sites (cg01546433 P=0.004835; cg24650785 P=0.000259 and cg002298481 P=0.000672). Differential BDNF methylation was associated with exercise, with active exercise associated with lower methylation levels at three CpG sites (cg04481212 P=0.005; cg01546433 P=0.025 and cg00298481 P=0.035).
The BDNF SNP rs6265 did not have any association with bone mineral density in women in northern Mexico.
There was no association between the extended psychosis phenotype and BDNF rs6265/COMT rs4680 polymorphisms. The lack of an association between different expression levels of the extended psychosis phenotype and the BDNF rs6265/ COMT rs4680 polymorphism might be related to sample characteristics, underlying gene-gene, gene-environment and gene-environment-gene interactions.
The carriers of the BDNF variants rs6265 is at increased risk of dyskinesia.
Studies indicate the role of brain derived neurotrophic factor (BDNF) and its associated pathways in susceptibility to Schizophrenia (Scz), Alzheimer's (AD), and Parkinson's (PD) diseases [Review].
Studied use of cocaine- and amphetamine-regulated transcript protein (CART) and brain derived neurotrophic factor (BDNF) as biomarkers for obesity in a follow up cohort after gastric bypass for morbid obesity.
The Met allele of the BDNF Val66Met polymorphism may be involved in the generalized Anxiety disorder in a sample of Southeast Mexican population.
This study demonstrated that that BDNF expression level is correlated with RIMS1 expression, a gene involved in the process of exocytosis of synaptic vesicles.
Study found a significant interaction between BDNF Val66Met genotype group and image valence on post-sleep recognition performance. This interaction was driven by greater memory for negative and positive images, relative to neutral images, in Met carriers. Study also found that longer Rapid Eye Movement (REM) sleep duration predicted greater post-sleep recognition performance for negative images in Met carriers.
Authors believe our multimodal imaging data provide the first demonstration in women that the effects of the BDNF Val/Met polymorphism on hippocampal function are selectively modulated by estradiol.
Data suggest that the percentage of methylation of the brain derived neurotrophic factor (BDNF) gene could be used as a prognostic factor for disease progression toward a high disability in Multiple Sclerosis (MS) atient.
A functional SNP in BDNF gene (rs6265 196 G/A is responsible for substitution of valine by methionine on 66th amino acid position) seems to confer protective effect on obsessive compulsive disorder.
review summarizes data regarding the changes in brain BDNF expression after nicotine or cigarette smoke exposure, and discusses their implications considering BDNF's functional roles.
The Val66Met polymorphism in the BDNF gene is associated with impaired fear extinction learning in individuals with post-traumatic stress disorder (PTSD).
The results of the present study indicated that BDNF gene polymorphism plays a prominent role in the variation of symptoms among insomnia patients
Met allele of Val66Met polymorphism in BDNF gene seems to impair cognitive function in individuals with bipolar disorder.
This study provides evidence of moderate quality that blood levels of BDNF are decreased in Parkinson's disease patients despite various influencing factors.
Results show that BDNF haploinsufficiency substantially decreases the neuroprotective effect of the steroid mifepristone on Purkinje neurons. This suggests that a full expression of BDNF is critical to prevent the neurotoxicity induced by the GABAergic network activity.
Closer examination of genes implicated in the mechanisms of neuroplasticity, such as the NMDA and AMPA subunits and the BDNF pathway, reveal how wild-type mice upregulate many of these genes in response to stress, but Met allele carriers fail to do so.
This study found that BDNF deletion in the adult altered few itch or acute and chronic pain behaviors, beyond sexually dimorphic phenotypes in the tail immersion, histamine, and formalin tests.
CA3-specific deletion of BDNF results in deficits in circuits that process social cues from familiar conspecifics.
findings suggest that reductions in concentrations of BDNF results in altered status of excitability and excitation/inhibition imbalance.
It has been shown that the Wnt3a/beta-catenin/BDNF axis in the spinal neural circuit plays an important role in regulating capsaicin-induced pain.
High BDNF expression is associated with anxiety and memory disorders in Huntington's disease.
These data suggested an anxiogenic- and antidepressant-like phenotype of ELA2 knockout, possibly associated with increased levels of BDNF in the prefrontal cortex.
Prep1 deficiency alters olfactory morpho-functional integrity and olfaction-mediated eating behavior by affecting BDNF-TrkB signaling.
Electroconvulsive therapy in an animal model of depression increases BDNF expression in the cerebral cortex.
results provide evidence that adaptations in cortical (mPFC) BDNF activity resulting from chronic ethanol exposure play a role in mediating excessive ethanol drinking associated with dependence.
These results provide further evidence that Bdnf splice variants generate a spatial code that mediates the local actions of BDNF in distinct dendritic compartments on structural and functional plasticity.
Study demonstrated up-regulation of miR-210-3p by MPP+ reduces the brain-derived neurotrophic factor production and contributes to the dopaminergic neuron damage.
we found that the effect of genipin on PRS mice occurs through DNA demethylation by inhibiting DNA methyltransferase 1 (DNMT1), normalizing the expression of reduced brain-derived neurotrophic factor (BDNF) in the hippocampus
glucose administration increased phosphorylated Akt, phosphorylated CREB, exon 1- and exon 4-specific BDNF transcripts, and FGF1 transcripts that are associated with the epigenetic changes.
the BDNF-EPO-Shh novel-signaling pathway underlies the regulation of inflammatory responses.
BDNF regulates the timing of neurodevelopment via a novel mechanism of extranuclear sequestration of NFATc4 in Golgi. This leads to accelerated derepression of an NFI temporal occupancy gene program in cerebellar granule cells that includes Bdnf itself, revealing an autoregulatory loop within the program driven by BDNF and NFATc4.
An acute bout of exercise can recover BDNF-TrkB signalling in the prefrontal cortex of obese, glucose intolerant mice.
Results give strong evidence for a cell type-specific brain derived neurotrophin factor (BDNF), TrkB signaling in modulating neuronal architecture. Study propose that a BDNF-independent transactivation of TrkB receptor may be able to compensate the lack of BDNF signaling to modulate neuronal morphology in a cell type-specific manner.
These results suggest that psychological stress during gestation can induce long-term mood alterations in pregnant mice, which may correlate with changes in miR-206-3p and BDNF expression in the hippocampus, mPFC and amygdala.
Zebrafish brain possesses intense neurogenesis that can be correlated with high regenerative properties. Recently, the zebrafish has been proposed as a valid experimental paradigm to study the association of BDNF and neural repair after traumatic brain injury.[review]
BDNF is involved in the gonadal function of adult zebrafish, and mainly in the adult ovary.
One of the modulators of TOR is brain-derived neurotrophic factor (BDNF), which activates the TOR signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.
These results suggest an involvement of the BDNF/TrkB system in the regulation of food intake and energy balance in zebrafish, as in mammals
BDNF-TrkB influences the expression level of components of chemokine signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons
The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB in zebrafish.
The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript
Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin knockdown in zebrafish.
Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.
BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway
activity-dependent conversion of proBDNF to mBDNF may regulate synapse elimination.
Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein .
These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.
In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC-derived alphaMSH, and that the light controls the biosynthesis and secretion of BDNF and of POMC end-products.
BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.
BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.
BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis
BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.
PACAP stimulates the expression of BDNF transcript IV.
The upstream open reading frames of BDNF transcripts I and IV markedly decrease BDNF translation efficiency, giving the first indication for a functional role of untranslated BDNF exons.
measurement of brain derived neurotrophic factor in serum brings a practical approach to study the effects of environmental enrichment on neurobiological changes in domestic animals
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.
Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin and leptin.
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
Study showed that complex relationships exist between BDNF/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC expressions are strongly correlated with spontaneous physical activity.
A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
, brain derived neurothrophic factor
, brain derived neurotrophic factor
, anorexia BDNF
, brain-derived neurotrophic factor
, neurotrophic factor