(Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Hegde, Capell, Ibrahim, Klett, Patel, Sougiannis, Kelly: "Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 41, Issue 12, pp. 2920-2931, (2017) (PubMed).
Passariello, Gayanilo, Kritzer, Thakur, Cozacov, Rusconi, Wieczorek, Sanders, Li, Kapiloff: "p90 ribosomal S6 kinase 3 contributes to cardiac insufficiency in ?-tropomyosin Glu180Gly transgenic mice." in: American journal of physiology. Heart and circulatory physiology, Vol. 305, Issue 7, pp. H1010-9, (2013) (PubMed).
Roux, Richards, Blenis: "Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity." in: Molecular and cellular biology, Vol. 23, Issue 14, pp. 4796-804, (2003) (PubMed).
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).