Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008].
Bhatnagar, Gazin, Chamberlain, Ou, Zhu, Tushir, Virbasius, Lin, Zhu, Wajapeyee, Green: "TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein." in: Nature, Vol. 516, Issue 7529, pp. 116-20, (2014) (PubMed).
Aliases for RNF2 蛋白
ring finger protein 2 (RNF2) 蛋白 ring finger protein 2 (Rnf2) 蛋白 ring finger protein 2 (rnf2) 蛋白 ring finger protein 2 L homeolog (rnf2.L) 蛋白 AI326319 蛋白 AI450156 蛋白 AU019207 蛋白 BAP-1 蛋白 bap-1 蛋白 BAP1 蛋白 bap1 蛋白 DING 蛋白 dinG 蛋白 ding 蛋白 fa19h05 蛋白 HIPI3 蛋白 hipi3 蛋白 RING1B 蛋白 Ring1B 蛋白 ring1b 蛋白 RING2 蛋白 ring2 蛋白 wu:fa19h05 蛋白 wz4556 蛋白