The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].
custom-made
RNF111
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, SDS, WB
custom-made
RNF111
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, SDS, WB
ring finger protein 111 (RNF111) 蛋白 ring finger 111 (Rnf111) 蛋白 ring finger protein 111 (Rnf111) 蛋白 ring finger protein 111 (rnf111-b) 蛋白 ring finger protein 111 (rnf111) 蛋白 ARK 蛋白 ark 蛋白 Arkadia 蛋白 MGC81253 蛋白 MGC146379 蛋白 RNF111 蛋白 rnf111 蛋白