RNF111 产品
(Ring Finger Protein 111 (RNF111))
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The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].
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Recommended RNF111 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, RNAi
Validations
- (9)
- (5)
Cat. No.
ABIN527194
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
- (3)
Cat. No.
ABIN527193
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (2)
Cat. No.
ABIN6257485
Quantity
100 μL
Datasheet
Datasheet
Recommended RNF111 蛋白
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Reactivity
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Source
Wheat germ
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- (1)
Cat. No.
ABIN1318194
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
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Cat. No.
ABIN3095070
Quantity
1 mg
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Reactivity
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ABIN3136968
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Datasheet
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Latest Publications for our RNF111 Products
: "The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma." in: Oncogene, Vol. 35, Issue 27, pp. 3514-23, (2016) (PubMed).: "SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair." in: Nature communications, Vol. 6, pp. 7499, (2015) (PubMed).
: "Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-? signalling." in: Nature communications, Vol. 5, pp. 3388, (2014) (PubMed).
: "Multiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control." in: Molecular and cellular biology, Vol. 34, Issue 16, pp. 2981-95, (2014) (PubMed).
: "RNF111-dependent neddylation activates DNA damage-induced ubiquitination." in: Molecular cell, Vol. 49, Issue 5, pp. 897-907, (2013) (PubMed).
: "Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation." in: Molecular and cellular biology, Vol. 33, Issue 11, pp. 2163-77, (2013) (PubMed).
: "RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response." in: The Journal of cell biology, Vol. 201, Issue 6, pp. 797-807, (2013) (PubMed).
: "Efficient TGF-?/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression." in: Molecular cancer, Vol. 10, Issue 1, pp. 2, (2011) (PubMed).
: "RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity." in: The Journal of biological chemistry, Vol. 286, Issue 37, pp. 32502-12, (2011) (PubMed).
: "Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells." in: Journal of biochemistry, Vol. 147, Issue 4, pp. 545-54, (2010) (PubMed).
Synonyms and alternative names related to RNF111
ring finger protein 111 (RNF111), ring finger 111 (Rnf111), ring finger protein 111 (Rnf111), ring finger protein 111 (rnf111-b), ring finger protein 111 (rnf111), ARK, ark, Arkadia, MGC81253, MGC146379, RNF111, rnf111Protein level used designations for RNF111
- Arkadia
- E3 ubiquitin-protein ligase Arkadia
- RING finger protein 111
- ring finger 111
- arkadia
- ring finger protein 111
- E3 ubiquitin-protein ligase arkadia-B
- RING finger protein 111-B
- e3 ubiquitin-protein ligase Arkadia-like
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