RNASEH2A 抗体
(Ribonuclease H2, Subunit A (RNASEH2A))
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| RNASEH2A 抗体 | 人, 大鼠, 小鼠 | 兔 Polyclonal |
|
|
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人, 大鼠, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
Latest Publications for our RNASEH2A 抗体
: "CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. ..." in: Nature, Vol. 559, Issue 7713, pp. 285-289, (2019) (PubMed).
: "Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition." in: Oncogene, (2018) (PubMed).
: "RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation." in: Frontiers in immunology, Vol. 9, pp. 587, (2018) (PubMed).
: "The core spliceosome as target and effector of non-canonical ATM signalling." in: Nature, Vol. 523, Issue 7558, pp. 53-8, (2015) (PubMed).
: "Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3623-33, (2015) (PubMed).
: "Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition." in: Oncogene, (2018) (PubMed).
: "RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation." in: Frontiers in immunology, Vol. 9, pp. 587, (2018) (PubMed).
: "The core spliceosome as target and effector of non-canonical ATM signalling." in: Nature, Vol. 523, Issue 7558, pp. 53-8, (2015) (PubMed).
: "Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3623-33, (2015) (PubMed).
Aliases for RNASEH2A 抗体
ribonuclease H2 subunit A (rnaseh2a) 抗体ribonuclease H2 subunit A (RNASEH2A) 抗体
ribonuclease H2, large subunit (Rnaseh2a) 抗体
ribonuclease H2, subunit A (rnaseh2a) 抗体
ribonuclease H2 subunit A L homeolog (rnaseh2a.L) 抗体
ribonuclease H2, subunit A (RNASEH2A) 抗体
ribonuclease H2, subunit A (Rnaseh2a) 抗体
2400006P09Rik 抗体
AGS4 抗体
JUNB 抗体
RNASEHI 抗体
RNHIA 抗体
RNHL 抗体
zgc:56307 抗体
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