RIPK1 抗体
(Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
Latest Publications for our RIPK1 抗体
: "Isolation and characterization of cluster of differentiation 9-positive ependymal cells as potential adult neural stem/progenitor cells in the third ventricle of adult rats." in: Cell and tissue research, Vol. 379, Issue 3, pp. 497-509, (2020) (PubMed).
: "Modulation of lung cancer cell plasticity and heterogeneity with the restoration of cisplatin sensitivity by neurotensin antibody." in: Cancer letters, Vol. 444, pp. 147-161, (2019) (PubMed).
: "Silencing of A20 Aggravates Neuronal Death and Inflammation After Traumatic Brain Injury: A Potential Trigger of Necroptosis." in: Frontiers in molecular neuroscience, Vol. 12, pp. 222, (2019) (PubMed).
: "Necroptosis in pulmonary macrophages mediates lipopolysaccharide-induced lung inflammatory injury by activating ZBP-1." in: International immunopharmacology, Vol. 77, pp. 105944, (2019) (PubMed).
: "Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression." in: Scientific reports, Vol. 9, Issue 1, pp. 17369, (2019) (PubMed).
: "TDP-43 accelerates age-dependent degeneration of interneurons." in: Scientific reports, Vol. 7, Issue 1, pp. 14972, (2018) (PubMed).
: "Targeting necroptotic cell death pathway by high-intensity interval training (HIIT) decreases development of post-ischemic adverse remodelling after myocardial ischemia / reperfusion injury." in: Journal of cell communication and signaling, (2018) (PubMed).
: "Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors." in: BMC cancer, Vol. 16, pp. 545, (2017) (PubMed).
: "Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis." in: Cell death & disease, Vol. 7, Issue 6, pp. e2287, (2016) (PubMed).
: "The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression." in: Nature, Vol. 532, Issue 7598, pp. 245-9, (2016) (PubMed).
: "Modulation of lung cancer cell plasticity and heterogeneity with the restoration of cisplatin sensitivity by neurotensin antibody." in: Cancer letters, Vol. 444, pp. 147-161, (2019) (PubMed).
: "Silencing of A20 Aggravates Neuronal Death and Inflammation After Traumatic Brain Injury: A Potential Trigger of Necroptosis." in: Frontiers in molecular neuroscience, Vol. 12, pp. 222, (2019) (PubMed).
: "Necroptosis in pulmonary macrophages mediates lipopolysaccharide-induced lung inflammatory injury by activating ZBP-1." in: International immunopharmacology, Vol. 77, pp. 105944, (2019) (PubMed).
: "Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression." in: Scientific reports, Vol. 9, Issue 1, pp. 17369, (2019) (PubMed).
: "TDP-43 accelerates age-dependent degeneration of interneurons." in: Scientific reports, Vol. 7, Issue 1, pp. 14972, (2018) (PubMed).
: "Targeting necroptotic cell death pathway by high-intensity interval training (HIIT) decreases development of post-ischemic adverse remodelling after myocardial ischemia / reperfusion injury." in: Journal of cell communication and signaling, (2018) (PubMed).
: "Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors." in: BMC cancer, Vol. 16, pp. 545, (2017) (PubMed).
: "Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis." in: Cell death & disease, Vol. 7, Issue 6, pp. e2287, (2016) (PubMed).
: "The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression." in: Nature, Vol. 532, Issue 7598, pp. 245-9, (2016) (PubMed).
Aliases for RIPK1 抗体
receptor interacting serine/threonine kinase 1 (RIPK1) 抗体receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1) 抗体
receptor interacting serine/threonine kinase 1 (Ripk1) 抗体
receptor interacting serine/threonine kinase 1 L homeolog (ripk1.L) 抗体
D330015H01Rik 抗体
Rinp 抗体
RIP 抗体
RIP1 抗体
Rip1 抗体
rip1 抗体
ripk1 抗体
xrip1 抗体
xRIP1beta 抗体
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