Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Zhang, Gao, Coots, Conn, Liu, Qian: "Translational control of the cytosolic stress response by mitochondrial ribosomal protein L18." in: Nature structural & molecular biology, Vol. 22, Issue 5, pp. 404-10, (2015) (PubMed).
Sun, Dai, Lu: "5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 8052-9, (2007) (PubMed).
Aliases for Ribosomal Protein L5 抗体
ribosomal protein L5 (Rpl5) 抗体 ribosomal protein L5 (RPL5) 抗体 60S ribosomal protein L5 (rpl-5) 抗体 Ribosomal protein L5 (RpL5) 抗体 ribosomal protein L5 L homeolog (rpl5.L) 抗体 50S ribosomal protein L5 (rpl5) 抗体 ribosomal protein L5 (rpl5) 抗体 ribosomal protein L5 S homeolog (rpl5.S) 抗体 ribosomal protein L5 (RpL5) 抗体 ribosomal protein L5b (rpl5b) 抗体 rpl5 (rpl5) 抗体 ribosomal protein L5a (rpl5a) 抗体 CG17489 抗体 DBA6 抗体 Dmel\\CG17489 抗体 dRPL5 抗体 E-2d 抗体 L5 抗体 M(2)40B 抗体 mg:cb01f08 抗体 Rp L5 抗体 Rpl5 抗体 rpl5 抗体 rpl5l 抗体 U21RNA 抗体 wu:fj02g05 抗体 yip6 抗体 zgc:56511 抗体 zgc:77176 抗体 zgc:86854 抗体