The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008].
Wang, Lippman, Lee, Yang, Khuri, Kim, Lin, Chang, Lotan, Hong, Wu: "Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma." in: Carcinogenesis, Vol. 31, Issue 10, pp. 1755-61, (2010) (PubMed).
Bansal, DiVietro, Kuehn, Rao, Nocka, Gilfillan, Druey: "RGS13 controls g protein-coupled receptor-evoked responses of human mast cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 11, pp. 7882-90, (2008) (PubMed).
Bansal, Xie, Rao, Nocka, Druey: "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13." in: Nature immunology, Vol. 9, Issue 1, pp. 73-80, (2007) (PubMed).
Han, Huang, Kim, Kehrl: "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization." in: Journal of leukocyte biology, Vol. 79, Issue 6, pp. 1357-68, (2006) (PubMed).
Islam, Asplund, Lindvall, Nygren, Liden, Kimby, Christensson, Smith, Sander: "High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma." in: Leukemia, Vol. 17, Issue 9, pp. 1880-90, (2003) (PubMed).
Aliases for RGS13 抗体
regulator of G protein signaling 13 (RGS13) 抗体 regulator of G-protein signaling 13 (Rgs13) 抗体 RGD1562103 抗体