(Regulatory Factor X, 1 (Influences HLA Class II Expression) (RFX1))
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. [provided by RefSeq, Jul 2008].
Julien, Chassagne, Peccate, Lorain, Piétri-Rouxel, Danos, Benkhelifa-Ziyyat: "RFX1 and RFX3 Transcription Factors Interact with the D Sequence of Adeno-Associated Virus Inverted Terminal Repeat and Regulate AAV Transduction." in: Scientific reports, Vol. 8, Issue 1, pp. 210, (2018) (PubMed).
Zhu, Li, Yang, Tian, Wang, Yuan, Dong, He, Wang, Li: "Dynamics of the Transcriptome during Human Spermatogenesis: Predicting the Potential Key Genes Regulating Male Gametes Generation." in: Scientific reports, Vol. 6, pp. 19069, (2016) (PubMed).
Su, Tseng, Hsu, Tai, Huang, Ko, Lin, Liu, Chen, Shiau: "RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells." in: Oncotarget, Vol. 5, Issue 13, pp. 4909-19, (2014) (PubMed).