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Data suggest that analysis of S100P concentration in duodenal fluid (DF), in combination with routine screening upper gastrointestinal endoscopy (GIE), may facilitate the detection of pancreatic ductal adenocarcinoma (PDAC).
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S100A2 and S100P can be used as specific duct markers in eccrine sweat glands, and combined use of S100P or S100A2 with keratins enables easy to distinction between secretory coils and ducts.
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Data show that inhibition of S100 calcium binding protein P (S100P) results in reversing trastuzumab resistance (TzR) in proto-oncogene protein HER-2 (HER2)-driven breast cancers.
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the S100P protein may contribute to the outgrowth of aggressive tumor cells resistant to cytotoxic therapy and promote cancer progression.
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Results found high plasma levels of S100P protein in patients with metastatic breast cancer which suggest its implication in disease progression.
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activation of tissue plasminogen activator via the C-terminal lysine of S100P contributes to the enhancement of cell invasion by S100P and thus potentially to its metastasis-promoting activity.
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This study reveals significant association between blood-based decreased S100P methylation and Breast cancer (BC), and provides another proof for the application of altered DNA methylation signatures from blood cells as potential markers for the detection of BC, especially for the early stage.
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Novel positive feedback loop between Trx-1 and S100P promotes colorectal cancer invasion and metastasis.
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An S100P-positive biliary epithelial field is a preinvasive intraepithelial neoplasm in nodular-sclerosing cholangiocarcinoma.
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We established a novel quantitative analysis for the S100P protein in EUS-FNA samples which, when combined with EUS-FNA cytology, could provide promising results for the reliable diagnosis of pancreatic adenocarcinoma (PCA)
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S100P achieved 96.4% sensitivity, 93.3% specificity, 98.2% PPV, 87.5% NPV and 95.8% total accuracy, while IMP3 achieved 91.2% sensitivity, 86.7% specificity, 96.2% PPV, 72.2% NPV and 90.3% total accuracy for pancreatic ductal adenocarcinoma (PDA).Both markers were sensitive and specific for diagnosis of PDA.
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we demonstrate that cadmium inhibits S100P expression and cell proliferation in placenta, meanwhile, S100P expression affects cell proliferation
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Results indicate that overexpression of S100P is related with an invasive and metastatic phenotype of CRC which is EMT-involved and RAGE dependent.
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S100P in first trimester placenta was significantly less in spontaneous abortion patients than in normal pregnant women. Up-regulation of S100P in JAR cells promoted JAR cells proliferation, and increased the expression of p38 MAPK and pERK MAPK
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Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7.
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Keap1 functions as a suppressor of tumor metastasis by targeting the Nrf2/S100P pathway in NSCLC cells.
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Results suggest that SOX9 promotes tumor metastasis and invasion through regulation of S100P expression in colon cancer.
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LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2/M phase in gallbladder cancer by down-regulating S100P via the PI3K/AKT pathway.
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The highly specific IL-11 - S100P interaction occurring under physiologically relevant conditions should be taken into consideration upon development of the antineoplastics inhibiting IL-11 signaling.
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S100P expression in prostate cancer tissue was significantly decreased, whereas CD147 and OCT4 expression was increased. Their expression levels were closely associated with TNM stage and distant metastasis.
