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抗Rat (Rattus) 抗体:
抗Mouse (Murine) 抗体:
NF-YC was significantly increased in gliomas. Knockdown of NF-YC reduced brain tumor size in vivo. NF-YC played as an independent predictor of patient survival.
p53 (显示 TP53 抗体) negatively regulates the expression of the PRR11-SKA2 (显示 FAM33A 抗体) bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 (显示 FAM33A 抗体) bidirectional transcription unit after loss of p53 (显示 TP53 抗体) might contribute to tumorigenesis.
TAF12 (显示 TAF12 抗体) and NFYC are transcription factors that regulate the epigenome, whereas RAD54L (显示 ATRX 抗体) plays a central role in DNA repair
the expression of the adipogenic differentiation genes fatty acid binding protein-4, adiponectin, and leptin (显示 LEP 抗体) and the formation of fat droplets were impaired.
NFY-C expression was elevated in colorectal adenocarcinomas; moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease
The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA (显示 NFYA 抗体) both binds to NF-YB (显示 NFYB 抗体)/NF-YC and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box.
Sp1 (显示 PSG1 抗体), NF-Y and FOXO (显示 FOXO3 抗体) transcription factors are involved in the regulation of LKB1 (显示 STK11 抗体) transcription.
NF-YC functions as a new corepressor of agonist-bound mineralocorticoid receptor (显示 NR3C2 抗体) via alteration of aldosterone-induced MR conformation
role in repressing Smad2 (显示 SMAD2 抗体) and Smad3 (显示 SMAD3 抗体) transactivating activity
The NF-YB (显示 NFYB 抗体)/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.
NF-Y binds to p73 (显示 ARHGAP24 抗体) and transcriptionally regulates platelet derived growth factor beta receptor
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
CAAT box DNA-binding protein subunit C
, CCAAT binding factor subunit C
, CCAAT transcription binding factor subunit gamma
, histone H1 transcription factor large subunit 2A
, nuclear transcription factor Y subunit C
, nuclear transcription factor Y subunit gamma
, transactivator HSM-1
, transactivator HSM-1/2
, transcription factor NF-Y, C subunit
, nuclear transcription factor-Y gamma
, nuclear transcription factor Y, gamma
, CAAT-box DNA-binding protein subunit C
, CCAAT binding factor of CBF-C/NFY-C
, CCAAT-binding transcription factor subunit C