RECQL2 抗体
(Werner syndrome RecQ like helicase (WRN))
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008].
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Latest Publications for our RECQL2 抗体
: "Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome." in: Internal medicine (Tokyo, Japan), Vol. 58, Issue 1, pp. 109-113, (2019) (PubMed).: "WRN helicase is a synthetic lethal target in microsatellite unstable cancers. ..." in: Nature, Vol. 568, Issue 7753, pp. 551-556, (2019) (PubMed).
: "miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment." in: Molecular carcinogenesis, Vol. 57, Issue 2, pp. 295-302, (2018) (PubMed).
: "DNA2 drives processing and restart of reversed replication forks in human cells." in: The Journal of cell biology, Vol. 208, Issue 5, pp. 545-62, (2015) (PubMed).
: "The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa." in: Nucleic acids research, Vol. 42, Issue 19, pp. 12027-40, (2014) (PubMed).
: "Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling." in: DNA repair, Vol. 12, Issue 2, pp. 128-39, (2013) (PubMed).
: "Identification and characterization of SMARCAL1 protein complexes." in: PLoS ONE, Vol. 8, Issue 5, pp. e63149, (2013) (PubMed).
: "Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase." in: PLoS ONE, Vol. 7, Issue 6, pp. e35229, (2012) (PubMed).
: "Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein." in: The Journal of biological chemistry, Vol. 287, Issue 50, pp. 42312-23, (2012) (PubMed).
: "Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation." in: Molecular and cellular biology, Vol. 30, Issue 6, pp. 1382-96, (2010) (PubMed).
Aliases for RECQL2 抗体
Werner syndrome RecQ like helicase (WRN) 抗体mediator of RNA polymerase II transcription subunit 34 (LOC9327212) 抗体
Bloom syndrome RecQ like helicase (blm) 抗体
Werner syndrome RecQ like helicase (Wrn) 抗体
Werner syndrome, RecQ helicase-like L homeolog (wrn.L) 抗体
AI846146 抗体
ffa-1 抗体
recq2 抗体
RECQ3 抗体
RECQL2 抗体
recql2 抗体
RECQL3 抗体
recql3 抗体
RGD1564788 抗体
xBLM 抗体
xwrn 抗体
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