RCHY1 抗体
(Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1))
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including TP53, HDAC1 and CDKN1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
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Latest Publications for our RCHY1 抗体
: "p27kip1 Expression in non-small cell lung cancer is not an independent prognostic factor." in: Anticancer research, Vol. 30, Issue 9, pp. 3699-704, (2010) (PubMed).: "The Pirh2-keratin 8/18 interaction modulates the cellular distribution of mitochondria and UV-induced apoptosis." in: Cell death and differentiation, Vol. 16, Issue 6, pp. 826-37, (2009) (PubMed).
: "Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains." in: The Journal of biological chemistry, Vol. 284, Issue 33, pp. 21955-70, (2009) (PubMed).
: "Molecular basis of Pirh2-mediated p53 ubiquitylation." in: Nature structural & molecular biology, Vol. 15, Issue 12, pp. 1334-42, (2008) (PubMed).
: "Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53." in: The EMBO journal, Vol. 26, Issue 13, pp. 3062-74, (2007) (PubMed).
: "Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells." in: Experimental cell research, Vol. 312, Issue 17, pp. 3370-8, (2006) (PubMed).
: "Activation of p53 in cervical cancer cells by human papillomavirus E6 RNA interference is transient, but can be sustained by inhibiting endogenous nuclear export-dependent p53 antagonists." in: Cancer research, Vol. 66, Issue 24, pp. 11817-24, (2006) (PubMed).
: "Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3." in: The EMBO journal, Vol. 24, Issue 9, pp. 1739-49, (2005) (PubMed).
: "Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer." in: Journal of the National Cancer Institute, Vol. 96, Issue 22, pp. 1718-21, (2004) (PubMed).
Aliases for RCHY1 抗体
ring finger and CHY zinc finger domain containing 1 (RCHY1) 抗体ring finger and CHY zinc finger domain containing 1 (Rchy1) 抗体
ring finger and CHY zinc finger domain containing 1 (rchy1) 抗体
ring finger and CHY zinc finger domain containing 1 L homeolog (rchy1.L) 抗体
ARNIP 抗体
arnip 抗体
CHIMP 抗体
chimp 抗体
harnip 抗体
PIRH2 抗体
Pirh2 抗体
pirh2 抗体
PRO1996 抗体
pro1996 抗体
RCHY1 抗体
RNF199 抗体
rnf199 抗体
wu:fb37e07 抗体
Zfp363 抗体
zgc:101128 抗体
ZNF363 抗体
Znf363 抗体
znf363 抗体
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