RASSF1 产品
(Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))
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This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011].
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Featured RASSF1 Categories
RASSF1 抗体
High quality antibodies with extensive validation data.
RASSF1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
RASSF1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RASSF1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
- (4)
Cat. No.
ABIN673764
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN6264654
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IF, IHC
Validations
- (3)
Cat. No.
ABIN7256220
Quantity
200 μL
Datasheet
Datasheet
Recommended RASSF1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6959049
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1154468
Quantity
96 tests
Datasheet
Datasheet
Recommended RASSF1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN1098704
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317520
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317522
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our RASSF1 Products
: "An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma." in: Oncotarget, Vol. 8, Issue 12, pp. 19712-19722, (2017) (PubMed).: "Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer." in: Biochemical genetics, Vol. 55, Issue 4, pp. 322-334, (2017) (PubMed).
: "CpG island promoter hypermethylation of Ras association domain family 1A gene contributes to gastric carcinogenesis." in: Molecular medicine reports, Vol. 11, Issue 4, pp. 3039-46, (2015) (PubMed).
: "Decreased expression of RASSF1A tumor suppressor gene is associated with worse prognosis in clear cell renal cell carcinoma." in: International journal of oncology, Vol. 48, Issue 1, pp. 55-66, (2015) (PubMed).
: "The RASSF1A tumor suppressor regulates XPA-mediated DNA repair." in: Molecular and cellular biology, Vol. 35, Issue 1, pp. 277-87, (2014) (PubMed).
: "CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine." in: Biochemical and biophysical research communications, Vol. 402, Issue 3, pp. 507-14, (2010) (PubMed).
: "Hypermethylation of RASSF1A in human and rhesus placentas." in: The American journal of pathology, Vol. 170, Issue 3, pp. 941-50, (2007) (PubMed).
: "Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 22, pp. 6626-36, (2006) (PubMed).
: "The tumor suppressor RASSF1A in human carcinogenesis: an update." in: Histology and histopathology, Vol. 20, Issue 2, pp. 645-63, (2005) (PubMed).
: "Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter." in: Molecular and cellular biology, Vol. 25, Issue 10, pp. 3923-33, (2005) (PubMed).
Synonyms and alternative names related to RASSF1
NPR2-like, GATOR1 complex subunit (NPRL2), Ras association (RalGDS/AF-6) domain family 1 (rassf1), Ras association domain family member 1 (RASSF1), putative rassf1 (Smp_157340), Ras association domain family member 1 L homeolog (rassf1.L), Ras association (RalGDS/AF-6) domain family member 1 (Rassf1), Ras association domain family member 1 (Rassf1), 123F2, AA536941, AU044980, NORE2A, RASSF1, RASSF1A, Rassf1A, Rassf1B, Rassf1C, RDA32, REH3P21, wu:fc17f02, zgc:92505, zgc:112224Protein level used designations for RASSF1
- Ras association (RalGDS/AF-6) domain family 1
- Ras association (RalGDS/AF-6) domain family member 1
- ras association domain-containing protein 1
- Ras association domain family 1
- rassf1
- WUGSC:H_LUCA12.5
- cardiac-specific ras association domain family 1 protein
- pancreas-specific ras association domain family 1 protein
- tumor suppressor protein RDA32
- 123F protein
- RASSF1A tumor suppressor
- protein 123F2
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