This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011].
Latest Publications for our RAP1 GTPase Activating Protein 抗体
Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: "Tissue profiling of the mammalian central nervous system using human antibody-based proteomics." in: Molecular & cellular proteomics : MCP, Vol. 8, Issue 7, pp. 1612-22, (2009) (PubMed).
Aliases for RAP1 GTPase Activating Protein 抗体
RAP1 GTPase activating protein (RAP1GAP) 抗体 Rap1 GTPase-activating protein (Rap1gap) 抗体 RAP1 GTPase activating protein 1 (RAP1GAP1) 抗体 RAP1 GTPase activating protein L homeolog (rap1gap.L) 抗体 Rap1 GTPase-activating protein 1 (Tsp_09520) 抗体 RAP1 GTPase activating protein (rap1gap) 抗体 si:dkey-166d12.2 (si:dkey-166d12.2) 抗体 RAP1 GTPase activating protein (Rap1gap) 抗体 1300019I11Rik 抗体 2310004O14Rik 抗体 AI427470 抗体 DKFZp459A114 抗体 RAP1 抗体 RAP1GA1 抗体 Rap1ga1 抗体 rap1ga1 抗体 RAP1GAP 抗体 RAP1GAP1 抗体 rap1gap1 抗体 RAP1GAPII 抗体 rap1gapii 抗体 RAPGAP 抗体 rapgap 抗体 zgc:175180 抗体