This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011].
Capdevila-Busquets, Badiola, Arroyo, Alcalde, Soler-López, Aloy: "Breast cancer genes PSMC3IP and EPSTI1 play a role in apoptosis regulation." in: PLoS ONE, Vol. 10, Issue 1, pp. e0115352, (2015) (PubMed).
Cho, Dilley, Lampson, Greenberg: "Interchromosomal homology searches drive directional ALT telomere movement and synapsis." in: Cell, Vol. 159, Issue 1, pp. 108-21, (2014) (PubMed).
Aliases for PSMC3IP 抗体
PSMC3 interacting protein (PSMC3IP) 抗体 homologous-pairing protein 2 homolog (LOC726449) 抗体 homologous-pairing protein 2 homolog (LOC100165513) 抗体 Homologous-pairing protein 2 homolog (hop2) 抗体 PSMC3 interacting protein (psmc3ip) 抗体 homologous-pairing protein 2 homolog (LOC100633854) 抗体 homologous-pairing protein 2 homolog (LOC100650062) 抗体 homologous-pairing protein 2 homolog-like (LOC789362) 抗体 Tat-binding protein 1(Tbp-1)-interacting protein (TBPIP) (AHP2) 抗体 proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein (Psmc3ip) 抗体 PSMC3 interacting protein (Psmc3ip) 抗体 PSMC3 interacting protein L homeolog (psmc3ip.L) 抗体 Arabidopsis Hop2 homolog 抗体 C79099 抗体 GT198 抗体 Gt198 抗体 HOP2 抗体 HUMGT198A 抗体 ODG3 抗体 PSMC3IP 抗体 T6J4.9 抗体 T6J4_9 抗体 Tbpip 抗体 TBPIP 抗体 zgc:86785 抗体