Thymic Stromal Lymphopoietin Protein (TSLP)
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北京 101111
Quick Overview for Thymic Stromal Lymphopoietin Protein (TSLP) (ABIN988257)
抗原
See all Thymic Stromal Lymphopoietin (TSLP) 蛋白生物活性
宿主
资源
纯度
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序列
- MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC L EQVSQLQG L WRRFNRPL LK Q
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产品特性
- Fully biologically active when compared to standard. The ED50 as measured by its ability to induce proliferation of human IL-7Rª and human TSLP R co-transfected mouse BaF3 cells is less than 0.3 ng/ml,corresponding to a specific activity of > 3.3×106 units/mg.
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内毒素水平
- Level Less than 1EU/µg of rHuTSLP as determined by LAL method
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Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) protein (His-Avi Tag)
TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159), (R127A), (R130A) (Active) protein (Biotin,His-Avi Tag)TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159), (R127A), (R130A) protein (His-Avi Tag)TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) (Active) protein (Biotin,His-Avi Tag)TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) (Active) protein (His tag)TSLP 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Thymic Stromal Lymphopoietin (TSLP) (Active) protein (His tag)TSLP 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE. Active
Thymic Stromal Lymphopoietin (TSLP) (Active) protein (His tag)TSLP 宿主: Cynomolgus 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by reducing SDS-PAGE. Active
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) protein (Fc Tag)TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) (Active) protein (His tag)TSLP 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) (Active) protein (His tag,AVI tag,Biotin)TSLP 宿主: 人 宿主: HEK-293 Cells Recombinant >85 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
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储存条件
- 4 °C
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- Thymic Stromal Lymphopoietin (TSLP)
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背景
- TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rª) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naive T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFª) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Synonym: Thymic Stromal Lymphopoietin ( TSLP), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.
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分子量
- Approximately 15.0 KDa, a single non-glycosylated polypeptide chain containing 132 amino acids.
抗原
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