Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human T-lymphocytes is less than 20 ng/ml, corresponding to a specific activity of >, 5.0 × 104 IU/mg.
内毒素水平
Level Less than 1EU/µg of rHuMIP-3ª/CCL20 as determined by LAL method
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
4 °C
抗原
CCL20
(Chemokine (C-C Motif) Ligand 20 (CCL20))
别名
MIP-3 alpha/CCL20
背景
MIP-3 alpha/CCL20, also known as LARC (Liver and Activation-regulated Chemokine) and as Exodus, is a CC chemokine that is expressed in the liver, lymph nodes, appendix, PBL and lung and can signal through the CCR6 receptor. MIP-3 alpha is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors. Synonym: MIP-3 alpha/CCL20, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 100mM NaCl.
分子量
8.0 kDa, a single non-glycosylated polypeptide chain containing 70 amino acids.