IL-21 蛋白
Quick Overview for IL-21 蛋白 (ABIN988060)
抗原
See all IL-21 (IL21) 蛋白生物活性
宿主
资源
纯度
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序列
- QGQDRHMIRM RQLIDIVDQL KNYVNDLVPE FLPAPEDVET NCEWSAFSCF QKAQLKSANT GNNERIINVS IKKLKRKPPS TNAGRRQKHR LTCPSCDSYE KKPPKEFLER FKSLLQKMIH QHLSSRTHGS ED
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产品特性
- Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using human peripheral blood mononuclear cells is less than 10 ng/ml, corresponding to a specific activity of >, 1.0 × 105 IU/mg.
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内毒素水平
- Level Less than 1EU/µg of rHuIL-21 as determined by LAL method
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Interleukin 21 (IL21) (AA 32-162) protein
IL21 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 21 (IL21) (AA 30-162) protein (Fc Tag)IL21 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Interleukin 21 (IL21) (AA 30-162) (Active) proteinIL21 宿主: 人 宿主: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active
Interleukin 21 (IL21) (AA 32-162) protein (His-Avi Tag,Biotin)IL21 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 21 (IL21) (AA 18-146) protein (His-IF2DI Tag)IL21 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 21 (IL21) (AA 25-155) protein (His-IF2DI Tag)IL21 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 21 (IL21) proteinIL21 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
Interleukin 21 (IL21) protein (His tag)IL21 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
Interleukin 21 (IL21) (AA 18-146) protein (His-Avi Tag,Biotin)IL21 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 21 (IL21) (AA 1-162) protein (GST tag)IL21 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
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储存条件
- 4 °C
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- IL-21 (IL21) (Interleukin 21 (IL21))
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别名
- Interleukin-21 (IL-21)
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背景
- IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (gamma,c) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Synonym: Interleukin-21 (IL-21), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
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分子量
- Approximately 15.4 kDa, a single non-glycosylated polypeptide chain containing 133 amino acids.
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途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
抗原
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