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IL-21 Protein (His tag)

IL21 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % as determined by SDS-PAGE
产品编号 ABIN7320586
发货至: 中国
  • 抗原 See all IL-21 (IL21) 蛋白
    IL-21 (IL21) (Interleukin 21 (IL21))
    蛋白类型
    Recombinant
    宿主
    • 32
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    小鼠
    资源
    • 23
    • 16
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    大肠杆菌(E. Coli)
    标记
    This IL-21 protein is labelled with His tag.
    原理
    Recombinant Mouse Interleukin-21/IL-21 Protein (His Tag)
    序列
    Pro25-Ser146
    产品特性
    Recombinant Mouse Interleukin-21 is produced by our E.coli expression system and the target gene encoding Pro25-Ser146 is expressed with a 6His tag at the N-terminus.
    纯度
    > 95 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product IL21 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    IL-21 (IL21) (Interleukin 21 (IL21))
    别名
    Interleukin-21/IL-21 (IL21 产品)
    别名
    IL-21 Protein, Za11 Protein, interleukin 21 Protein, IL21 Protein, Il21 Protein
    背景

    Background: Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66 % ,59 %, 58 %, and 88 % aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells. It is required for the migration of dendritic cells to draining lymph nodes .It co-stimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells.

    Synonym: Interleukin-21,IL-21,IL21,Il21

    分子量
    14.4 kDa
    UniProt
    Q9ES17
    途径
    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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