IGFBP3 蛋白
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北京 101111
Quick Overview for IGFBP3 蛋白 (ABIN987984)
抗原
See all IGFBP3 蛋白生物活性
宿主
资源
纯度
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序列
- GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQS
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产品特性
- Fully biologically active when compared to standard. The ED50 determined by inhibiting IGF-II induced proliferation ofserum free human MCF-7 cells is less than 200 ng/ml, corresponding to a specific activity of >, 5.0 × 103 IU/mg in the presence of 15ng/ml of rHuIGF-II.
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内毒素水平
- Level Less than 1EU/µg of rHuIGF-BP3 as determined by LAL method
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Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (Active) protein
IGFBP3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 120-244) protein (His tag)IGFBP3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) (AA 28-291) protein (His tag)IGFBP3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
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储存条件
- 4 °C
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- IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))
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别名
- IGF-BP3
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背景
- IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in ª-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Synonym: IGF-BP3, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.
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分子量
- 28.8 kDa protein consisting of 264 amino acid residues.
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途径
- Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
抗原
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