CXCL13 蛋白
Quick Overview for CXCL13 蛋白 (ABIN987766)
抗原
See all CXCL13 蛋白蛋白类型
生物活性
宿主
资源
纯度
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序列
- VLEVYYTSLR CRCVQESSVF IPRRFIDRIQ ILPRGNGCPR KEIIVWKKNK SIVCVDPQAE WIQRMMEVLR KRSSSTLPVP VFKRKI
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产品特性
- Measured by its ability to chemoattract human CXCR5 transfected BaF3 mouse pro-B cells.The ED50 for this effect is typically 0.005-0.02 µg/mL,corresponding to a specific activity of > 5.0×104 units/mg.
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内毒素水平
- Level Less than 1EU/µg of rHuBCA-1/CXCL13 as determined by LAL method
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Chemokine (C-X-C Motif) Ligand 13 (CXCL13) (AA 22-109) protein (Fc Tag)
CXCL13 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Chemokine (C-X-C Motif) Ligand 13 (CXCL13) (AA 22-109) protein (His tag)CXCL13 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Chemokine (C-X-C Motif) Ligand 13 (CXCL13) (AA 23-109) protein (Fc Tag)CXCL13 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Chemokine (C-X-C Motif) Ligand 13 (CXCL13) (AA 23-109) protein (His-SUMO Tag)CXCL13 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Chemokine (C-X-C Motif) Ligand 13 (CXCL13) (AA 1-109) protein (GST tag)CXCL13 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Chemokine (C-X-C Motif) Ligand 13 (CXCL13) (AA 23-109) protein (His tag)CXCL13 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Chemokine (C-X-C Motif) Ligand 13 (CXCL13) (AA 23-109) protein (GST tag)CXCL13 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
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储存条件
- 4 °C
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- CXCL13 (Chemokine (C-X-C Motif) Ligand 13 (CXCL13))
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别名
- BCA-1/CXCL13
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背景
- CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. BCA-1 cDNA encodes a protein of 109 amino acid residues with a leader sequence of 22 residues. Mature human BCA-1 shares 64% amino acid sequence similarity with the mouse protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitts lymphoma cells, has now been shown to be the specific receptor for BCA-1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer's patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas Synonym: BCA-1/CXCL13, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 100mM NaCl.
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分子量
- 10.3 kDa, a single non-glycosylated polypeptide chain containing 87 amino acids.
抗原
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