SFRP1 蛋白
Quick Overview for SFRP1 蛋白 (ABIN935792)
抗原
See all SFRP1 蛋白蛋白类型
生物活性
宿主
资源
纯度
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序列
- SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK
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产品特性
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Purified recombinant Human sFRP1 protein
Expression System: HeLa cells
Bioactivity: Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3-0.5 µg/mL. -
内毒素水平
- < 0.1 ng per µg (1 EU/µg).
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Secreted Frizzled-Related Protein 1 (SFRP1) (AA 32-314) protein (His tag)
SFRP1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Secreted Frizzled-Related Protein 1 (SFRP1) (AA 1-314) protein (GST tag)SFRP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Secreted Frizzled-Related Protein 1 (SFRP1) proteinSFRP1 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Supplied as a lyophilized powder.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- SFRP1 (Secreted Frizzled-Related Protein 1 (SFRP1))
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别名
- sFRP1
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背景
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Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas.
Alternative Names: SFRP-1 protein, Secreted Frizzled Related Protein 1 protein, sFRP-1 protein, sFRP 1, sFRP 1 protein, Secreted Apoptosis Related Protein-2 protein, sFRP-1, sFRP1, Soluble Frizzled Related Protein-1 protein, SARP-2 protein -
途径
- WNT signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance, Tube Formation, Positive Regulation of fat Cell Differentiation
抗原
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