RANK Receptor (Active) 蛋白
This Recombinant protein is expressed in 大肠杆菌（E. Coli）.
Quick Overview for RANK Receptor (Active) 蛋白 (ABIN935751)
抗原
RANK Receptor
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 98 % pure
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序列
- MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK
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产品特性
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Purified recombinant Human RANK Receptor protein
Expression System: E.coli
Bioactivity: Determined by its ability to suppress the production of IFN-gamma from human PBMCs. -
内毒素水平
- < 0.1 ng per µg (1 EU/µg).
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute in water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- Lyophilized from 10 mM Na3PO4, pH 7.2.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- RANK Receptor
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背景
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RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naive T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2).
Alternative Names: TNFRSF11A protein, osteoclast differentiation factor receptor protein, ODFR protein, osteoclast differentiation and activation receptor protein, ODAR protein, TRANCE Receptor protein -
分子量
- 19.3 kDa
抗原
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