RANK Receptor (Soluble) (Active) 蛋白
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
< 98 % by SDS-PAGE gel and HPLC analyses.
Active
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- 抗原
- RANK Receptor
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- Soluble
- 宿主
- 人
- 资源
- 大肠杆菌（E. Coli）
- 序列
- MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK
- 产品特性
- Biological activity was determined by its ability to suppress the production of IFN - gamma from human PBMCs.
- 纯度
- < 98 % by SDS-PAGE gel and HPLC analyses.
- 内毒素水平
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 注意事项
- As with any protein, exposing Soluble RANK Receptor recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- 储存条件
- -20 °C
- 储存方法
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Soluble RANK Receptor is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
- 有效期
- 24 months
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- 抗原
- RANK Receptor
- 背景
- RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate na ve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).
- 基因ID
- 8792
- NCBI登录号
- NP_001257878
- OMIM
- 401015111
- UniProt
- Q9Y6Q6
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