NOG 蛋白
Quick Overview for NOG 蛋白 (ABIN935687)
抗原
See all NOG 蛋白蛋白类型
生物活性
宿主
资源
纯度
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序列
- QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC
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产品特性
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Purified recombinant Human Noggin protein
Expression System: 293 cells
Bioactivity: Determined by its ability to inhibit 5.0 ng/mL of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/mL of Noggin. -
内毒素水平
- < 0.1 ng per µg (1 EU/µg).
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Noggin (NOG) (AA 20-232) (Active) protein
NOG 宿主: 小鼠 宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Noggin (NOG) (AA 28-232) proteinNOG 宿主: 人 宿主: CHO Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Noggin (NOG) (AA 28-232) (Active) proteinNOG 宿主: 人 宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Noggin (NOG) protein (His tag)NOG 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Noggin (NOG) (AA 28-232) protein (His tag)NOG 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Noggin (NOG) (AA 28-232) protein (GST tag)NOG 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Noggin (NOG) protein (Fc Tag)NOG 宿主: 人 宿主: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Noggin (NOG) (AA 28-232) protein (Fc Tag)NOG 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.
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缓冲液
- Supplied lyophilized with no additives.
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储存液
- Without preservative
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- NOG (Noggin (NOG))
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别名
- Noggin
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背景
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Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF beta family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF beta ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2, -7, -13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system.
Alternative Names: SYM1 protein, NOG protein, SYM 1 protein, SYNS 1 protein, Symphalangism 1 (proximal) protein, Synostoses (multiple) syndrome 1 protein, SYNS1 protein -
分子量
- 46 kDa
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途径
- Stem Cell Maintenance, Tube Formation
抗原
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