NOV Protein (full length)
Quick Overview for NOV Protein (full length) (ABIN935685)
抗原
See all NOV 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- full length
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序列
- MQVAATQRCP PQCPGRCPAT PPTCAPGVRA VLDGCSCCLV CARQRGESCS DLEPCDESSG LYCDRSADPS NQTGICTAVE GDNCVFDGVI YRSGEKFQPS CKFQCTCRDG QIGCVPRCQL DVLLPEPNCP APRKVEVPGE CCEKWICGPD EEDSLGGLTL AAYRPEATLG VEVSDSSVNC IEQTTEWTAC SKSCGMGFST RVTNRNRQCE MLKQTRLCMV RPCEQEPEQP TDKKGKKCLR TKKSLKAIHL QFKNCTSLHT YKPRFCGVCS DGRCCTPHNT KTIQAEFQCS PGQIVKKPVM VIGTCTCHTN CPKNNEAFLQ ELELKTTRGK M
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产品特性
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Purified recombinant Human NOV protein
Expression System: E.coli
Bioactivity: Determined by a cell proliferation assay using BALB/c 3T3 cells. The expected ED50 for this effect is 1.0-2.0 µg/mL -
内毒素水平
- < 0.1 ng per µg (1 EU/µg).
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Nephroblastoma Overexpressed (NOV) (AA 1-357) protein (GST tag)
NOV 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Nephroblastoma Overexpressed (NOV) protein (His tag)NOV 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Nephroblastoma Overexpressed (NOV) (AA 28-357) protein (His tag)NOV 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Supplied as a lyophilized powder.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- NOV (Nephroblastoma Overexpressed (NOV))
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别名
- NOV
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背景
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NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm's tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities.
Alternative Names: Nephroblastoma Overexpressed gene protein, CCN3 protein, NovH protein, IGFBP9 protein -
分子量
- 36.2 kDa
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途径
- Smooth Muscle Cell Migration, Growth Factor Binding
抗原
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