IL-21 蛋白
Quick Overview for IL-21 蛋白 (ABIN935561)
抗原
See all IL-21 (IL21) 蛋白蛋白类型
生物活性
宿主
资源
纯度
-
-
产品特性
-
Purified recombinant Human IL21 protein
Expression System: E.coli
Bioactivity: ED50 = 1.0-10 ng/mL, determined by the dose-dependant proliferation of human peripheral blood mononuclear cells.
-
-
Interleukin 21 (IL21) (AA 32-162) protein
IL21 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 21 (IL21) (AA 30-162) protein (Fc Tag)IL21 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Interleukin 21 (IL21) (AA 30-162) (Active) proteinIL21 宿主: 人 宿主: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active
Interleukin 21 (IL21) (AA 32-162) protein (His-Avi Tag,Biotin)IL21 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 21 (IL21) (AA 18-146) protein (His-IF2DI Tag)IL21 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 21 (IL21) (AA 25-155) protein (His-IF2DI Tag)IL21 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 21 (IL21) proteinIL21 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
Interleukin 21 (IL21) protein (His tag)IL21 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
Interleukin 21 (IL21) (AA 18-146) protein (His-Avi Tag,Biotin)IL21 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 21 (IL21) (AA 1-162) protein (GST tag)IL21 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
-
-
应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
-
实验流程
-
Protein quantitation was carried out by two independent methods. 1. UV spectroscopy at 280 nm using the absorbency value of 0.54 as the extinction coefficient for a 0.1 % (1 mg/mL) solution.
2. Analysis by RP-HPLC, using a standard solution of IL-21 as a Reference Standard. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- Supplied as a lyophilized powder.
-
注意事项
- Avoid repeated freeze/thaw cycles.
-
储存条件
- RT/-20 °C
-
-
- IL-21 (IL21) (Interleukin 21 (IL21))
-
别名
- IL21
-
背景
-
IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (°C) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Alternative Names: Za11 protein, Interleukin 21 protein, IL 21, IL-21, IL 21 protein, IL-21 protein, IL-21 protein, IL-21 protein, IL21 -
分子量
- 15,463 Da
-
途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
抗原
-
