Purified recombinant Human FGF basic protein Expression System: E.coli Bioactivity: Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ? 0.1 ng/mL corresponding to a specific activity of ? 1 x 10^7 units/mg. Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ? 1.0 ng/mL, corresponding to a specific activity of ? 1 x 10^6 units/mg.
FGF basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells. FGF basic signals through FGFR 1b, 1c, 2c, 3c and 4. Alternative Names: Fibroblast Growth Factor-basic protein, HBGF-2 protein, FGF-2 protein, Prostatropin protein