Epiregulin Protein (EREG)
Quick Overview for Epiregulin Protein (EREG) (ABIN935331)
抗原
See all Epiregulin (EREG) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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序列
- MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL
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产品特性
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Purified recombinant Human Epiregulin protein
Expression System: E.coli
Bioactivity: The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse Balb/3T3 cells is ? 2.0 ng/mL, corresponding to a specific activity of ? 5 x 10^5units/mg. -
内毒素水平
- < 0.1 ng per µg (1 EU/µg).
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Epiregulin (EREG) (AA 56-101) protein (Fc Tag)
EREG 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epiregulin (EREG) (AA 63-108) protein (Fc Tag)EREG 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Epiregulin (EREG) (AA 60-108) protein (His-IF2DI Tag)EREG 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Epiregulin (EREG) (AA 1-169) protein (GST tag)EREG 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Supplied as a lyophilized powder.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- RT/-20 °C
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- Epiregulin (EREG)
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别名
- Epiregulin
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背景
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Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
Alternative Names: EREG protein -
分子量
- 5.6 kDa
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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