DKK1 蛋白
-
- 抗原 See all DKK1 蛋白
- DKK1 (Dickkopf Homolog 1 (DKK1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- HEK-293T Cells
- 序列
- TLNSVLNSNA IKNLPPPLGG AAGHPGSAVS AAPGILYPGG NKYQTIDNYQ PYPCAEDEEC GTDEYCASPT RGGDAGVQIC LACRKRRKRC MRHAMCCPGN YCKNGICVSS DQNHFRGEIE ETITESFGND HSTLDGYSRR TTLSSKMYHT KGQEGSVCLR SSDCASGLCC ARHFWSKICK PVLKEGQVCT KHRRKGSHGL EIFQRCYCGE GLSCRIQKDH HQASNSSRLH TCQRH
- 产品特性
-
Human recombinant DKK1 protein
Expression System: 293 cells
Bioactivity: Determined by its ability to inhibit the proliferation of HCT116 colorectal carcinoma cells. Approximately 40 % growth inhibition was achieved at a DKK-1 concentration of 200ng/mL. - 纯度
- > 97 % pure
- 内毒素水平
- < 0.1 ng per µg (1 EU/µg).
- Top Product
- Discover our top product DKK1 蛋白
-
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (His-Avi Tag,Biotin)
DKK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (His tag)DKK1 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 32-142), (N-Term) protein (Fc-Avi Tag)DKK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 178-266), (C-Term) protein (Fc-Avi Tag,Biotin)DKK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 178-266), (C-Term) protein (Fc-Avi Tag)DKK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 32-142), (N-Term) protein (Fc-Avi Tag,Biotin)DKK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 1-272) protein (His tag)DKK1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Dickkopf Homolog 1 (DKK1) (AA 81-180) protein (GST tag)DKK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Dickkopf Homolog 1 (DKK1) (AA 1-266) protein (GST tag)DKK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Dickkopf Homolog 1 (DKK1) (AA 1-242) protein (GST tag)DKK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
-
- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- Lyophilized from PBS buffer, pH 7.4.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- RT/-20 °C
-
- 抗原
- DKK1 (Dickkopf Homolog 1 (DKK1))
- 别名
- DKK1 (DKK1 产品)
- 背景
-
DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/betacatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/betacatenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.
Alternative Names: Dickkopf-related protein-1 protein, DKK 1, Dickkopt-1 protein, SK protein, DKK-1 protein, DKK-1, DKK-1 protein, DKK 1 protein, DKK1 - 分子量
- 35-40 kDa
- 途径
- WNT signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
-
