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- 抗原 See all TPMT 蛋白
- TPMT (Thiopurine S-Methyltransferase (TPMT))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-245
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK
- 产品特性
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Purified recombinant Human TPMT protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. - 纯度
- > 95 % pure
- Top Product
- Discover our top product TPMT 蛋白
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Thiopurine S-Methyltransferase (TPMT) (AA 1-245) protein (GST tag)
TPMT 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Thiopurine S-Methyltransferase (TPMT) (AA 4-244), (partial) protein (GST tag)TPMT 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95 % ELISA
Thiopurine S-Methyltransferase (TPMT) protein (Myc-DYKDDDDK Tag)TPMT 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- TPMT protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Supplied as a liquid in 20 mM Tris, pH 8.0, containing 0.0 mM PMSF, and 0 mM EDTA.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- RT/-20 °C
- 储存方法
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- 抗原
- TPMT (Thiopurine S-Methyltransferase (TPMT))
- 别名
- TPMT (TPMT 产品)
- 别名
- MGC84277 Protein, AW106912 Protein, NHLRC1 Protein, thiopurine S-methyltransferase L homeolog Protein, thiopurine S-methyltransferase, tandem duplicate 2 Protein, thiopurine S-methyltransferase TpmT Protein, thiopurine S-methyltransferase Protein, Thiopurine S-methyltransferase Protein, thiopurine methyltransferase Protein, tpmt.L Protein, tpmt.2 Protein, tpmT Protein, MCA0794 Protein, Pnap_4948 Protein, Hhal_1383 Protein, TK90_1044 Protein, Slit_1144 Protein, Tint_0842 Protein, Fbal_3334 Protein, Celly_3188 Protein, Weevi_1737 Protein, Psefu_2696 Protein, Metme_3860 Protein, Tpmt Protein, TPMT Protein
- 背景
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TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine and azathioprine are used as chemotherapeutic agents. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity. Recombinant human TPMT was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: Thiopurine methyltransferase protein, Thiopurine S methyltransferase., Thiopurine S-methyltransferase HGNC:12014 protein, Thiopurine S-methyltransferase protein, TPMT protein, S adenosyl L methionine thiopurine S methyltransferase protein - 分子量
- 28 kDa (245 AA)
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