Leptin Protein (LEP)
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- 抗原 See all Leptin (LEP) 蛋白
- Leptin (LEP)
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC
- 产品特性
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Purified recombinant Human Leptin protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. - 纯度
- > 95 % pure
- Top Product
- Discover our top product LEP 蛋白
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- 应用备注
- Leptin protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Supplied as a liquid in PBS, pH 7.4.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- RT/-20 °C
- 储存方法
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- 抗原
- Leptin (LEP)
- 别名
- Leptin (LEP 产品)
- 背景
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Human leptin is a 16-kDa nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility. The function of leptin in regulating appetite and metabolism, as well as the possibility of using leptin as a therapeutic agent, are currently under intense investigation. Recombinant human leptin was overexpressed as insoluble protein aggregate in E. coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Alternative Names: Obesity protein, OB protein, Obesity homolog mouse protein, Leptin protein, Leptin Precursor Obesity Factor protein, Obesity factor protein, Leptin protein, LEP protein, Obese protein protein, Obesity Murine Homolog Leptin protein, Leptin Murine Obesity Homolog protein, , OBS protein - 分子量
- 16 kDa (147 AA)
- 途径
- JAK/STAT Signaling, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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