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Quick Overview for Caspase 2 蛋白 (ABIN925026)
抗原
See all Caspase 2 (CASP2) 蛋白蛋白类型
生物活性
宿主
资源
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产品特性
- ~10,000 units/mg. One unit cleaves 1nmole of the caspase substrate VDVAD-pNA per hour at 37°C in a reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT.
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Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 121-220) protein (GST tag)
CASP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 348-452) protein (His tag)CASP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 80 % SDS
Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 1-452) protein (GST tag)CASP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) (AA 2-452) protein (His-SUMO Tag)CASP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Reconstitute with PBS to 1 unit/µl.
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储存条件
- -80 °C
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- Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
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别名
- Caspase-2
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背景
- Caspase-2 (also known as Ich-1, Nedd-2) is a member of the interleukin-1 converting enzyme (ICE) family of cysteine proteases. Similar as other caspases, caspase-2 also exists in cells as an inactive proenzyme. During apoptosis, procaspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed form of caspase-2 consists of large (19 kDa) and small (12 kDa) subunits, which associate to form the active enzyme. The active recombinant human caspase-2 was expressed in E. coli. The expressed caspase-2 spontaneously undergoes auto-processing to yield the subunits characteristic of the native enzyme.
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway
抗原
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