PARP2 蛋白
Quick Overview for PARP2 蛋白 (ABIN925019)
抗原
See all PARP2 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- 380 units/mg (one unit synthesizes 1 nmole of poly(ADP-ribose) per min at 25°C, pH 7.5.
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纯化方法
- Affinity purified
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Mouse价格从 115,504.49 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Mouse价格从 172,528.32 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Poly (ADP-Ribose) Polymerase 2 (PARP2) (AA 1-559) protein (His tag)
custom-made PARP2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Poly (ADP-Ribose) Polymerase 2 (PARP2) (AA 1-583) protein (His tag)custom-made PARP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Poly (ADP-Ribose) Polymerase 2 (PARP2) (AA 430-583) protein (His-IF2DI Tag)PARP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
Poly (ADP-Ribose) Polymerase 2 (PARP2) (AA 435-534) protein (GST tag)PARP2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Poly (ADP-Ribose) Polymerase 2 (PARP2) protein (His tag)PARP2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- -80 °C
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- PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))
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别名
- PARP-2
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背景
- The cDNA encoding human poly(ADP-ribose) polymerase (PARP) was cloned by several groups simultaneously. With the discovery of new members (homologs) of the PARP family, PARP is newly referred to as PARP-1. The isolated cDNAs from mouse and human encode a protein with considerable homology to the catalytic domain of PARP-1. This protein, termed PARP-2, is a 64 kDa protein that contains a nuclear localization signal (NLS) and is activated by DNA breaks, although its DNA- binding domain is very different from that of PARP-1. In recent years evidence has accumulated that poly(ADP-ribose) polymerase (PARP) plays a role in DNA repair and a substantial effort has been invested to elucidate the physiological function of the PARP pathway in cellular recovery from DNA damage. PARP has been found in the base excision repair (BER) complex with DNA polymerase-, ligase III and x-ray repair cross-complementing 1 (XRCC1). PARP- 1 and PARP-2, even though lacking the zinc- finger domains, bind to single and double strand breaks during oxidative stress. In general, it appears that an early enzymatic activation of PARP occurs upon DNA-strand break formation. Binding of PARP to a DNA nick may then cause a transient halt to cellular activity and protect the DNA from sister chromatid associated proteins such as histones. Nicotinamide is cleaved in this step from the substrate NAD+ by PARP and the so synthesized poly(ADP)-ribose (PAR) is then used to generate ATP. Specific
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途径
- DNA Damage Repair
抗原
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