Neuregulin 1 Protein (NRG1) (AA 2-246)
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Quick Overview for Neuregulin 1 Protein (NRG1) (AA 2-246) (ABIN8057045)
抗原
See all Neuregulin 1 (NRG1) 蛋白蛋白类型
宿主
资源
纯度
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产品特性
- AA 2-246
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原理
- Recombinant Human Pro-Neuregulin-1/NRG1-β1 Protein (aa 2-246)
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序列
- Ser2-Lys246
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过滤
- 0.2 μm filtered
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内毒素水平
- < 0.01 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Neuregulin 1 (NRG1) (AA 20-242) protein (Fc Tag)
NRG1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Neuregulin 1 (NRG1) (AA 177-241) (Active) proteinNRG1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >90 % as determined by SDS-PAGE. SDS, WB, Imm, ELISA, AcA Active
Neuregulin 1 (NRG1) (AA 119-237) protein (His-IF2DI Tag)NRG1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Neuregulin 1 (NRG1) (AA 177-241) protein (His-IF2DI Tag)NRG1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Neuregulin 1 (NRG1) (AA 1-241) protein (GST tag)NRG1 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Neuregulin 1 (NRG1)
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别名
- Pro-Neuregulin-1
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背景
- EGF,GGF,HGL,HRG1-beta 1,HRGA,NDF,NRG1,NRG1-beta 1,Neuregulin-1 beta 1,Pro-neuregulin-1,SMDF,Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells, inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction, stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells, stimulating Schwann cell proliferation, implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
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分子量
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Calculated MW: 26.9 kDa
Observed MW: 34 kDa
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基因ID
- 3084
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UniProt
- Q02297
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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