MMP3 Protein (AA 18-477)
This Recombinant MMP3 protein is expressed in Mammalian Cells.
产品编号 ABIN8057038
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for MMP3 Protein (AA 18-477) (ABIN8057038)
抗原
See all MMP3 蛋白
MMP3
(Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))
蛋白类型
Recombinant
宿主
人
资源
Mammalian Cells
应用范围
Immunogen (Imm)
纯度
> 95 % as determined by reducing SDS-PAGE.
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产品特性
- AA 18-477
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原理
- Recombinant Human MMP-3(Lys45Glu) Protein(Halo Tag)
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序列
- Tyr18-Cys477(Lys45Glu)
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU/mg of the protein as determined by the LAL method
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Biological Activity Comment
- Not validated for activity
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Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) (AA 100-477) protein (His tag)
MMP3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) (AA 1-477) protein (GST tag)MMP3 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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缓冲液
- Lyophilized from a 0.2 μm filtered solution in PBS with 5 % Trehalose and 5 % Mannitol.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))
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别名
- MMP-3
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背景
- Stromelysin-1,SL-1,Matrix metalloproteinase-3,Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP3 can also active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.
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分子量
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Calculated MW: 83.4 kDa
Observed MW: 83 kDa
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基因ID
- 4314
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UniProt
- P08254
抗原
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