MMP3 蛋白
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北京 101111
Quick Overview for MMP3 蛋白 (ABIN7317858)
抗原
See all MMP3 蛋白蛋白类型
生物活性
宿主
资源
纯度
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原理
- Recombinant Human MMP-3 Protein
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序列
- Tyr 18-Thr 272
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产品特性
- A DNA sequence encoding the human MMP3 (AAA36321.1) N-terminal fragment (Tyr 18-Thr 272) was expressed and purified.
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过滤
- 0.2 μm filtered
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Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nva-WR-K(Dnp)-NH2, AnaSpec, Catalog # 27114.The specific activity is > 300 pmoles/min/μg. (Activation description: The proenzyme needs to be activated by Chymotrypsin for an activated form)
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Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) (AA 100-477) protein (His tag)
MMP3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) (AA 100-477), (full length) protein (His tag)MMP3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 85 % as determined by SDS-PAGE.
Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) (AA 1-477) protein (GST tag)MMP3 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile 50 mM Tris, 10 mM CaCL2, 1uM ZnCL2, 50 mM NaCl, 0.5 % Brij35, pH 7.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))
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别名
- MMP-3
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背景
- CHDS6,MMP-3,MMP3,Matrix metalloproteinase-3,SL-1,STMY,STMY1,STR1,Stromelysin-1,Transin-1,Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP3 can also active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.
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分子量
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Calculated MW: 29 kDa
Observed MW: 34 kDa
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基因ID
- 4314
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UniProt
- P08254
抗原
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