YES1 蛋白
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北京 101111
Quick Overview for YES1 蛋白 (ABIN7939737)
抗原
See all YES1 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant YES1 protein
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V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 1-543) protein (GST tag)
YES1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (Active) protein (GST tag,His tag)YES1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 80 % as determined by reducing SDS-PAGE. Active
V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) protein (Myc-DYKDDDDK Tag)YES1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant YES1 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))
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别名
- YES1
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背景
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Protein Background: YES1 (YES Proto-Oncogene 1, Src Family Tyrosine Kinase), a non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, YES1 promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly and participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, YES1 phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration and participates in CD95L/FASLG signaling pathway and mediates AKTmediated cell migration. YES1 plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase.
Short Description: Recombinant YES1 protein was expressed in baculovirus expression system as the full length protein (accession number NP_005424.1) with a N-terminal FLAG tag. The molecular weight of the protein is 62.1 kDa.
Aliases: YES Proto-Oncogene 1 , Src Family Tyrosine Kinase
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途径
- CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling
抗原
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