YES1 Protein (His-GST)
This Recombinant YES1 protein is expressed in Baculovirus infected Insect Cells.
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产品编号 ABIN7317062
发货至:
中国
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中国
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Quick Overview for YES1 Protein (His-GST) (ABIN7317062)
抗原
See all YES1 蛋白
YES1
(V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
Baculovirus infected Insect Cells
纯度
> 80 % as determined by reducing SDS-PAGE.
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标记
- This YES1 protein is labelled with His-GST.
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原理
- Recombinant Human c-Yes/YES1 Protein (His & GST Tag)
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序列
- Gly 2-Leu 543
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产品特性
- A DNA sequence encoding the human YES1 (NP_005424.1) (Gly 2-Leu 543) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 35 nmol/min/mg using Poly(Glu, Tyr) 4:1 as substrate.
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V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 1-543) protein (GST tag)
YES1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) protein (Myc-DYKDDDDK Tag)YES1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, 0.5 mM TCEP, pH 8.0
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))
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别名
- c-Yes/YES1
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背景
- HsT441,P61-YES,Yes,c-yes,Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains oneprotein kinase domain, oneSH2 domain and oneSH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase is known to be related to malignant transformation. YES1 / c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support redundancy in signaling between these two kinases. YES1 / c-Yes promotes formation of the tight junction by phosphorylating occludin, while c-Src signaling downregulates occludin formation in a Raf-1 dependent manner. YES1 / c-Yes has tyrosine kinase activity. It promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP / CD46.
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分子量
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Calculated MW: 88.5 kDa
Observed MW: 75 kDa
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基因ID
- 7525
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NCBI登录号
- NP_005424
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UniProt
- P07947
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途径
- CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling
抗原
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