UBE2W 蛋白
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北京 101111
Quick Overview for UBE2W 蛋白 (ABIN7939720)
抗原
See all UBE2W 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant UBE2W protein
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!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 HEK-293 CellsConjugate His tagOrigin Human价格从 116,946.14 ¥表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Human价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
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Ubiquitin-Conjugating Enzyme E2W (UBE2W) (AA 1-151) protein (His tag)
custom-made UBE2W 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Ubiquitin-Conjugating Enzyme E2W (UBE2W) (AA 1-159) protein (GST tag)UBE2W 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Ubiquitin-Conjugating Enzyme E2W (UBE2W) (AA 1-151) protein (His tag)UBE2W 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Ubiquitin-Conjugating Enzyme E2W (UBE2W) (AA 1-162) protein (His-IF2DI Tag)UBE2W 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Ubiquitin-Conjugating Enzyme E2W (UBE2W) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)UBE2W 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant UBE2W protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- UBE2W (Ubiquitin-Conjugating Enzyme E2W (UBE2W))
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别名
- UBE2W
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背景
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Protein Background: UBE2W (Ubiquitin-conjugating enzyme E2 W) is a member of the E2 ubiquitin-conjugating enzyme family which is required for postreplicative DNA damage repair and plays an important role in various cellular processes. UBE2W can accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway.
Short Description: Recombinant UBE2W protein that includes full length of human UBE2W protein (accession number NP_060769.5) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 19.49 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.
Aliases: Ubiquitin conjugating enzyme E2 W, UBC-16
抗原
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