STAT1 蛋白
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北京 101111
Quick Overview for STAT1 蛋白 (ABIN7939568)
抗原
See all STAT1 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant STAT1 protein
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Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-712) protein (GST tag)
STAT1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 613-712) protein (GST tag)STAT1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (AA 1-712) protein (His tag)STAT1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant STAT1 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
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别名
- STAT1
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背景
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Protein Background: STAT1 is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma),STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Short Description: Recombinant STAT1 protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_009330.1) with an N-terminal FLAG tag. The molecular weight of STAT1 is 88.61 kDa.
Aliases: STAT91, Signal Transducer and Activator of Transcription 1, CANDF7
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途径
- JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
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