RPS6KB1 蛋白
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Quick Overview for RPS6KB1 蛋白 (ABIN7939513)
抗原
See all RPS6KB1 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant RPS6KB1 protein
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Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) (AA 1-525) protein (GST tag)
RPS6KB1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) (AA 1-525) protein (His tag)RPS6KB1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 85 % SDS
Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) (AA 51-300) protein (His-IF2DI Tag)RPS6KB1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant RPS6KB1 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))
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别名
- RPS6KB1
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背景
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Protein Background: RPS6KB1 (Ribosomal Protein S6 Kinase B1) is a serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression.RPS6KB1 regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B.
Short Description: Recombinant RPS6KB1 protein was expressed in baculovirus expression system as the full length protein (accession number NP_003152.1) with a N-terminal FLAG tag. The molecular weight of the protein is 60.4 kDa.
Aliases: Ribosomal Protein S6 Kinase B1
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途径
- PI3K-Akt Signaling, RTK signaling, AMPK Signaling, Regulation of Cell Size, Skeletal Muscle Fiber Development, Feeding Behaviour, G-protein mediated Events, Smooth Muscle Cell Migration, Interaction of EGFR with phospholipase C-gamma, Warburg Effect
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