PKD2 蛋白
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Quick Overview for PKD2 蛋白 (ABIN7939476)
抗原
See all PKD2 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Recombinant PRKD2 protein
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Protein Kinase D2 (PKD2) (AA 1-878) protein (GST tag)
PKD2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein Kinase D2 (PKD2) (Active) protein (GST tag,His tag)PKD2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 82 % as determined by reducing SDS-PAGE. Active
Protein Kinase D2 (PKD2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PKD2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant PRKD2 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- PKD2 (Protein Kinase D2 (PKD2))
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别名
- PRKD2
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背景
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Protein Background: PRKD2 (Protein Kinase D2), a Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC and PRKD2 is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and PRKD2 plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PRKD2 may potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, PRKD2 is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. Diseases associated with PRKD2 include Angiolipoma and Mitochondrial Complex I Deficiency, Nuclear Type 1.
Short Description: Recombinant PRKD2 protein was expressed in baculovirus expression system as the full length protein (accession number NP_001073349.1) with a N-terminal FLAG tag. The molecular weight of the protein is 98 kDa.
Aliases: Protein Kinase D2, PKD2, Serine/threonine-protein kinase D2
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途径
- cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity
抗原
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