PD-1 Protein (AA 25-167)
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Quick Overview for PD-1 Protein (AA 25-167) (ABIN7939455)
抗原
See all PD-1 (PDCD1) 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 25-167
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原理
- Recombinant PDCD1 / PD1 (25-167) protein
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Programmed Cell Death 1 (PDCD1) (AA 25-167) (Active) protein (mFc Tag)
PDCD1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Programmed Cell Death 1 (PDCD1) (AA 24-170) protein (His tag,mFc Tag)PDCD1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Programmed Cell Death 1 (PDCD1) (AA 25-167) protein (His tag,Fc Tag)PDCD1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Programmed Cell Death 1 (PDCD1) (AA 25-167) (Active) protein (hFc Tag)PDCD1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Programmed Cell Death 1 (PDCD1) (AA 25-167) (Active) protein (Biotin,His-Avi Tag)PDCD1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Programmed Cell Death 1 (PDCD1) (AA 25-167) (Active) protein (hFc-Avi Tag,Biotin)PDCD1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Programmed Cell Death 1 (PDCD1) (AA 25-167) (Active) protein (hFc Tag,Biotin)PDCD1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Programmed Cell Death 1 (PDCD1) (AA 33-145) protein (His-DYKDDDDK-Strep II Tag)PDCD1 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Programmed Cell Death 1 (PDCD1) (AA 1-110) protein (GST tag)PDCD1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Programmed Cell Death 1 (PDCD1) (AA 22-170) protein (His-DYKDDDDK-Strep II Tag)PDCD1 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant PDCD1 / PD1 (25-167) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
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别名
- PDCD1 & PD1
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背景
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Protein Background: Programmed cell death protein 1 (PDCD1), inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. PDCD1 delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. PDCD1 suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Short Description: Recombinant PDCD1 / PD1 (25-167) protein that includes amino acids 25-167 of human PD1 protein (accession number NP_005009.2) was expressed in a baculovirus expression system, and contains an C-terminal FLAG tag. The molecular weight of the protein is 17.8 kDa.
Aliases: Programmed cell death protein 1
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途径
- Cancer Immune Checkpoints
抗原
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