PDGFRA Protein (AA 550-1089)
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北京 101111
Quick Overview for PDGFRA Protein (AA 550-1089) (ABIN7939422)
抗原
See all PDGFRA 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 550-1089
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原理
- Recombinant PDGFRA (550-1089) protein
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Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 24-524) (Active) protein (His tag)
PDGFRA 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 24-524) (Active) protein (Biotin,His-Avi Tag)PDGFRA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 24-524) (Active) protein (His-Avi Tag)PDGFRA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 25-218) protein (GST tag)PDGFRA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 24-524) (Active) protein (His tag)PDGFRA 宿主: 人 宿主: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, ELISA, Imm, AcA Active
Platelet Derived Growth Factor Receptor alpha (PDGFRA) protein (His tag)PDGFRA 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Platelet Derived Growth Factor Receptor alpha (PDGFRA) protein (Fc Tag)PDGFRA 宿主: 大鼠 宿主: HEK-293 Cells Recombinant (96.6+2.8) % as determined by SDS-PAGE
Platelet Derived Growth Factor Receptor alpha (PDGFRA) protein (Fc Tag)PDGFRA 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Platelet Derived Growth Factor Receptor alpha (PDGFRA) protein (His tag)PDGFRA 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 24-524) protein (His-IF2DI Tag)PDGFRA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant PDGFRA (550-1089) protein is supplied in 25 mM HEPES NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
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别名
- PDGFRA
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背景
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Protein Background: PDGFRA (Platelet Derived Growth Factor Receptor Alpha), a tyrosine-protein kinase that acts as a cell surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival, and chemotaxis. Depending on the context, PDGFRA promotes or inhibits cell proliferation and cell migration and plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. PDGFRA phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca (2+) and the activation of protein kinase C. PDGFRA phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. This protein also mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1 and promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B.
Short Description: Recombinant PDGFRA (550-1089) protein that includes amino acids 550-1089 of human PDGFRA protein (accession number NP_001334758.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 62.8 kDa.
Aliases: Platelet Derived Growth Factor Receptor Alpha
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
抗原
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